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Proteins/UNIPROT:P51553
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers..
Function from UniProtKB (P51553), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
59 statements
59 statements · 5 reference databases · Subject: IDH3G · Sources: Hetionet, Human-GEM, Reactome, UniProt, WikiPathways
7 reactions
ATP+CHEBI:15519+waterADP+CHEBI:15519+proton+phosphate(3-)
Transported by IDH3G or PDZD4 or ABCD1 or SRPK3 or BCAP31
Reaction pageLeft to rightBalancedcytosol, peroxisome
Human-GEM MAR01659CC BY 4.0Reference data
ATP+
2 names
Resolves to: IDH3G
Reaction pageLeft to rightBalancedcytosol, peroxisome
Human-GEM MAR03008CC BY 4.0Reference data
ATP+water+palmitoyl-CoAADP+proton+palmitoyl-CoA+phosphate(3-)
Transported by IDH3G or PDZD4 or ABCD1 or SRPK3 or BCAP31
Reaction pageLeft to rightBalancedcytosol, peroxisome
Human-GEM MAR03011CC BY 4.0Reference data
ATP+water+(9Z,12Z)-octadecadienoyl-CoAADP+proton+(9Z,12Z)-octadecadienoyl-CoA+phosphate(3-)
Transported by IDH3G or PDZD4 or ABCD1 or PNCK or SRPK3 or BCAP31
Reaction pageLeft to rightBalancedcytosol, peroxisome
Human-GEM MAR03013CC BY 4.0Reference data
arachidonoyl-CoA+ATP+waterADP+arachidonoyl-CoA+proton+phosphate(3-)
Transported by IDH3G or PDZD4 or ABCD1 or PNCK or BCAP31
Reaction pageLeft to rightBalancedcytosol, peroxisome
Human-GEM MAR03014CC BY 4.0Reference data
(13Z)-eicosenoyl-CoA+ATP+water(13Z)-eicosenoyl-CoA+ADP+proton+phosphate(3-)
Transported by IDH3G or PDZD4 or ABCD1 or PNCK or BCAP31
Reaction pageLeft to rightBalancedcytosol, peroxisome
Human-GEM MAR03017CC BY 4.0Reference data
isocitric acid+NAD(+)2-oxoglutarate(2-)+carbon dioxide+NADH(2-)
Catalysed by IDH3B & IDH3A & IDH3G
Reaction pageLeft to rightBalancedEC 1.1.1.41mitochondrial matrix
Human-GEM MAR03957CC BY 4.0Reference data