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Proteins/UNIPROT:Q9UKN8
Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box..
Function from UniProtKB (Q9UKN8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
26 statements
26 statements · 3 reference databases · Subject: GTF3C4 · Sources: Hetionet, Human-GEM, Reactome
2 reactions
7 names
Resolves to: GTF3C4
Human-GEM MAR09495CC BY 4.0Reference data
L-lysyl-[protein]+acetyl-CoAN(6)-acetyl-L-lysyl-[protein]+coenzyme A(4-)+hydron
Catalysed by HAT1 or CLOCK or TAF1 or BLOC1S1 or GTF2B or EP300 or NCOA1 or ESCO2 or ESCO1 or KAT6B or CREBBP or KAT6A and 12 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:45948CC BY 4.0Reference data