TATDN2

Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA structure. Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates. May have a role in maintaining genomic stability through its role in R-loop resolution..

Function from UniProtKB (Q93075), read 2026-09-23. CC BY 4.0.