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Proteins/UNIPROT:Q92831
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac). Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing. Acetylates MAPRE1/EB1, promoting dynamic kinetochore-microtubule interactions in early mitosis. Also acetylates spermidine..
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes..
Function from UniProtKB (Q92831), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
337 statements
337 statements · 8 reference databases · Subject: KAT2B · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
4 reactions
7 names
Resolves to: KAT2B
Human-GEM MAR09495CC BY 4.0Reference data
L-lysyl-[histone]+acetyl-CoAN(6)-acetyl-L-lysyl-[histone]+coenzyme A(4-)+hydron
Catalysed by MCM3AP or KAT7 or EP300 or CREBBP or KAT2A or KAT2B or KAT5 or KAT8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:21992CC BY 4.0Reference data
spermidine+acetyl-CoAN(8)-acetylspermidine+coenzyme A(4-)+hydron
Catalysed by KAT2B
Reaction pageLeft to rightBalanced
Rhea RHEA:28270CC BY 4.0Reference data
L-lysyl-[protein]+acetyl-CoAN(6)-acetyl-L-lysyl-[protein]+coenzyme A(4-)+hydron
Catalysed by HAT1 or CLOCK or TAF1 or BLOC1S1 or GTF2B or EP300 or NCOA1 or ESCO2 or ESCO1 or KAT6B or CREBBP or KAT6A and 12 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:45948CC BY 4.0Reference data