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Proteins/UNIPROT:Q12972
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.
Function from UniProtKB (Q12972), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
92 statements
92 statements · 4 reference databases · Subject: PPP1R8 · Sources: Hetionet, Reactome, UniProt, WikiPathways
7 names
Resolves to: PPP1R8