PPARA activates gene expression

1) genes involved in fatty acid oxidation and ketogenesis (Acox1, Cyp4a, Acadm, Hmgcs2);

2) genes involved in fatty acid transport (Cd36,, Slc27a1, Fabp1, Cpt1a, Cpt2);

3) genes involved in producing fatty acids and very low density lipoproteins (Me1, Scd1);

4) genes encoding apolipoproteins (Apoa1, Apoa2, Apoa5);

5) genes involved in triglyceride clearance ( Angptl4);

6) genes involved in glycerol metabolism (Gpd1 in mouse);

7) genes involved in glucose metabolism (Pdk4);

8) genes involved in peroxisome proliferation (Pex11a);

9) genes involved in lipid storage (Plin, Adfp).

Many other genes are known to be regulated by PPAR-alpha but whether their regulation is direct or indirect remains to be found. These genes include: ACACA, FAS, SREBP1, FADS1, DGAT1, ABCA1, PLTP, ABCB4, UGT2B4, SULT2A1, Pnpla2, Acsl1, Slc27a4, many Acot genes, and others (reviewed in Rakhshandehroo et al. 2010).