Proteins/UNIPROT:P01135

TGFA

ProteinUNIPROT:P01135

TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

Function from UniProtKB (P01135), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

tooth agenesis has a germline basis in TGFADiseaseGenCC HGNC:11765|MONDO:0005486Inferred only

Statements

155 statements

155 statements · 4 reference databases · Subject: TGFA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

TGFA covaries with TLNRD1ProteinHetionet hetionet:covaries:59274-7039Inferred only
ZNF655 covaries with TGFAProteinHetionet hetionet:covaries:7039-79027Inferred only
ADAM10 interacts with TGFAProteinHetionet hetionet:interacts:102-7039Inferred only
ADAM17 interacts with TGFAProteinHetionet hetionet:interacts:6868-7039Inferred only
EGFR interacts with TGFAProteinHetionet hetionet:interacts:1956-7039Inferred only
ELANE interacts with TGFAProteinHetionet hetionet:interacts:1991-7039Inferred only
ERBB4 interacts with TGFAProteinHetionet hetionet:interacts:2066-7039Inferred only
TGFA interacts with GORASP1ProteinHetionet hetionet:interacts:64689-7039Inferred only
TGFA interacts with GORASP2ProteinHetionet hetionet:interacts:26003-7039Inferred only
TGFA interacts with MAGI2ProteinHetionet hetionet:interacts:7039-9863Inferred only
TGFA interacts with MAGI3ProteinHetionet hetionet:interacts:260425-7039Inferred only
TGFA interacts with NKD2ProteinHetionet hetionet:interacts:7039-85409Inferred only

Show the remaining 143

TGFA interacts with RHBDF1ProteinHetionet hetionet:interacts:64285-7039Inferred only
SDCBP interacts with TGFAProteinHetionet hetionet:interacts:6386-7039Inferred only
SNTA1 interacts with TGFAProteinHetionet hetionet:interacts:6640-7039Inferred only
TGFA participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
TGFA participates in BMP signaling in eyelid developmentPathwayWikiPathways WP3927Inferred only
TGFA participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
TGFA participates in Cargo concentration in the ERPathwayReactome R-HSA-5694530Inferred only
TGFA participates in Cargo recognition for clathrin-mediated endocytosisPathwayReactome R-HSA-8856825Inferred only
TGFA participates in Clathrin-mediated endocytosisPathwayReactome R-HSA-8856828Inferred only
TGFA participates in Constitutive Signaling by Aberrant PI3K in CancerPathwayReactome R-HSA-2219530Inferred only
TGFA participates in COPII-mediated vesicle transportPathwayReactome R-HSA-204005Inferred only
TGFA participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
TGFA participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
TGFA participates in Developmental Cell Lineages of the Integumentary SystemPathwayReactome R-HSA-9734779Inferred only
TGFA participates in Developmental Lineage of Mammary Gland Luminal Epithelial CellsPathwayReactome R-HSA-9927418Inferred only
TGFA participates in Developmental Lineage of Mammary Gland Myoepithelial CellsPathwayReactome R-HSA-9927432Inferred only
TGFA participates in Developmental Lineages of the Mammary GlandPathwayReactome R-HSA-9924644Inferred only
TGFA participates in DiseasePathwayReactome R-HSA-1643685Inferred only
TGFA participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
TGFA participates in EGFR downregulationPathwayReactome R-HSA-182971Inferred only
TGFA participates in EGFR interacts with phospholipase C-gammaPathwayReactome R-HSA-212718Inferred only
TGFA participates in EGFR tyrosine kinase inhibitor resistancePathwayWikiPathways WP4806Inferred only
TGFA participates in ER to Golgi Anterograde TransportPathwayReactome R-HSA-199977Inferred only
TGFA participates in ErbB signalingPathwayWikiPathways WP673Inferred only
TGFA participates in ESR-mediated signalingPathwayReactome R-HSA-8939211Inferred only
TGFA participates in Estrogen-dependent gene expressionPathwayReactome R-HSA-9018519Inferred only
TGFA participates in Estrogen-dependent nuclear events downstream of ESR-membrane signalingPathwayReactome R-HSA-9634638Inferred only
TGFA participates in Extra-nuclear estrogen signalingPathwayReactome R-HSA-9009391Inferred only
TGFA participates in Extracellular vesicle mediated signaling in recipient cellsPathwayWikiPathways WP2870Inferred only
TGFA participates in Fumarate hydratase deficient papillary renal cell carcinomaPathwayWikiPathways WP4241Inferred only
TGFA participates in GAB1 signalosomePathwayReactome R-HSA-180292Inferred only
TGFA participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
TGFA participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
TGFA participates in GRB2 events in EGFR signalingPathwayReactome R-HSA-179812Inferred only
TGFA participates in Inhibition of Signaling by Overexpressed EGFRPathwayReactome R-HSA-5638303Inferred only
TGFA participates in Intracellular signaling by second messengersPathwayReactome R-HSA-9006925Inferred only
TGFA participates in Lung fibrosisPathwayWikiPathways WP3624Inferred only
TGFA participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
TGFA participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
TGFA participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
TGFA participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
TGFA participates in Negative regulation of the PI3K/AKT networkPathwayReactome R-HSA-199418Inferred only
TGFA participates in Non small cell lung cancerPathwayWikiPathways WP4255Inferred only
TGFA participates in NRF2 pathwayPathwayWikiPathways WP2884Inferred only
TGFA participates in Nuclear receptors meta pathwayPathwayWikiPathways WP2882Inferred only
TGFA participates in Pancreatic adenocarcinoma pathwayPathwayWikiPathways WP4263Inferred only
TGFA participates in Photodynamic therapy induced HIF 1 survival signalingPathwayWikiPathways WP3614Inferred only
TGFA participates in Physico chemical features and toxicity associated pathwaysPathwayWikiPathways WP3680Inferred only
TGFA participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
TGFA participates in PI3K/AKT Signaling in CancerPathwayReactome R-HSA-2219528Inferred only
TGFA participates in PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingPathwayReactome R-HSA-6811558Inferred only
TGFA participates in PIP3 activates AKT signalingPathwayReactome R-HSA-1257604Inferred only
TGFA participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
TGFA participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
TGFA participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
TGFA participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
TGFA participates in SHC1 events in EGFR signalingPathwayReactome R-HSA-180336Inferred only
TGFA participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
TGFA participates in Signaling by EGFRPathwayReactome R-HSA-177929Inferred only
TGFA participates in Signaling by EGFR in CancerPathwayReactome R-HSA-1643713Inferred only
TGFA participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
TGFA participates in Signaling by Overexpressed Wild-Type EGFR in CancerPathwayReactome R-HSA-5638302Inferred only
TGFA participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
TGFA participates in TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsPathwayReactome R-HSA-8866910Inferred only
TGFA participates in Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsPathwayReactome R-HSA-8864260Inferred only
TGFA participates in Transport to the Golgi and subsequent modificationPathwayReactome R-HSA-948021Inferred only
TGFA participates in Tyrosine kinase inhibitors in glioblastomaPathwayWikiPathways WP5494Inferred only
TGFA participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
TGFA regulates positive regulation of cell population proliferationBiological processgene ontology P01135|GO:0008284Inferred only
TGFA regulates positive regulation of epithelial cell proliferationBiological processgene ontology P01135|GO:0050679Inferred only
TGFA regulates positive regulation of MAPK cascadeBiological processgene ontology P01135|GO:0043410Inferred only
TGFA regulates positive regulation of mitotic nuclear divisionBiological processgene ontology P01135|GO:0045840Inferred only
TGFA increases the expression of ABCC5ProteinHetionet hetionet:regulates:7039-10057Inferred only
TGFA decreases the expression of ACSL5ProteinHetionet hetionet:regulates:7039-51703Inferred only
TGFA increases the expression of ATP6V1C1ProteinHetionet hetionet:regulates:7039-528Inferred only
TGFA decreases the expression of BAXProteinHetionet hetionet:regulates:7039-581Inferred only
TGFA increases the expression of CCR7ProteinHetionet hetionet:regulates:7039-1236Inferred only
TGFA decreases the expression of CDK1ProteinHetionet hetionet:regulates:7039-983Inferred only
TGFA increases the expression of CEBPGProteinHetionet hetionet:regulates:7039-1054Inferred only
TGFA increases the expression of CEMIP2ProteinHetionet hetionet:regulates:7039-23670Inferred only
TGFA increases the expression of CNOT4ProteinHetionet hetionet:regulates:7039-4850Inferred only
TGFA increases the expression of COL11A1ProteinHetionet hetionet:regulates:7039-1301Inferred only
TGFA decreases the expression of CSRP1ProteinHetionet hetionet:regulates:7039-1465Inferred only
TGFA decreases the expression of DCTDProteinHetionet hetionet:regulates:7039-1635Inferred only
TGFA decreases the expression of DPYSL2ProteinHetionet hetionet:regulates:7039-1808Inferred only
TGFA decreases the expression of EEF1A2ProteinHetionet hetionet:regulates:7039-1917Inferred only
TGFA increases the expression of EIF4ENIF1ProteinHetionet hetionet:regulates:7039-56478Inferred only
TGFA decreases the expression of EML3ProteinHetionet hetionet:regulates:7039-256364Inferred only
ERCC1 increases the expression of TGFAProteinHetionet hetionet:regulates:2067-7039Inferred only
TGFA increases the expression of FAT1ProteinHetionet hetionet:regulates:7039-2195Inferred only
GLI1 increases the expression of TGFAProteinHetionet hetionet:regulates:2735-7039Inferred only
TGFA increases the expression of GTF2F2ProteinHetionet hetionet:regulates:7039-2963Inferred only
TGFA decreases the expression of HDAC2ProteinHetionet hetionet:regulates:7039-3066Inferred only
TGFA decreases the expression of HSD17B11ProteinHetionet hetionet:regulates:7039-51170Inferred only
TGFA decreases the expression of IARS2ProteinHetionet hetionet:regulates:7039-55699Inferred only
TGFA decreases the expression of KIFBPProteinHetionet hetionet:regulates:7039-26128Inferred only
TGFA increases the expression of KLHL21ProteinHetionet hetionet:regulates:7039-9903Inferred only
TGFA decreases the expression of LDHBProteinHetionet hetionet:regulates:7039-3945Inferred only
TGFA decreases the expression of LGALS1ProteinHetionet hetionet:regulates:7039-3956Inferred only
TGFA decreases the expression of LIPAProteinHetionet hetionet:regulates:7039-3988Inferred only
TGFA increases the expression of LRPAP1ProteinHetionet hetionet:regulates:7039-4043Inferred only
TGFA increases the expression of MED4ProteinHetionet hetionet:regulates:7039-29079Inferred only
TGFA decreases the expression of MSNProteinHetionet hetionet:regulates:7039-4478Inferred only
TGFA increases the expression of NAXDProteinHetionet hetionet:regulates:7039-55739Inferred only
TGFA increases the expression of NCK2ProteinHetionet hetionet:regulates:7039-8440Inferred only
TGFA increases the expression of NCOA3ProteinHetionet hetionet:regulates:7039-8202Inferred only
TGFA increases the expression of NFIL3ProteinHetionet hetionet:regulates:7039-4783Inferred only
TGFA decreases the expression of NME1ProteinHetionet hetionet:regulates:7039-4830Inferred only
NR2F2 increases the expression of TGFAProteinHetionet hetionet:regulates:7026-7039Inferred only
NR2F6 increases the expression of TGFAProteinHetionet hetionet:regulates:2063-7039Inferred only
NXF1 increases the expression of TGFAProteinHetionet hetionet:regulates:10482-7039Inferred only
TGFA increases the expression of PAK1ProteinHetionet hetionet:regulates:7039-5058Inferred only
TGFA decreases the expression of PCBD1ProteinHetionet hetionet:regulates:7039-5092Inferred only
TGFA decreases the expression of PGAM1ProteinHetionet hetionet:regulates:7039-5223Inferred only
TGFA decreases the expression of PGRMC1ProteinHetionet hetionet:regulates:7039-10857Inferred only
TGFA decreases the expression of PIK3C2BProteinHetionet hetionet:regulates:7039-5287Inferred only
TGFA increases the expression of PLA2G15ProteinHetionet hetionet:regulates:7039-23659Inferred only
TGFA decreases the expression of PLPP2ProteinHetionet hetionet:regulates:7039-8612Inferred only
TGFA decreases the expression of PSME2ProteinHetionet hetionet:regulates:7039-5721Inferred only
TGFA increases the expression of PTPRGProteinHetionet hetionet:regulates:7039-5793Inferred only
TGFA decreases the expression of RFC2ProteinHetionet hetionet:regulates:7039-5982Inferred only
TGFA decreases the expression of RPA1ProteinHetionet hetionet:regulates:7039-6117Inferred only
RPL7 increases the expression of TGFAProteinHetionet hetionet:regulates:6129-7039Inferred only
RPS6KA1 decreases the expression of TGFAProteinHetionet hetionet:regulates:6195-7039Inferred only
RRM1 increases the expression of TGFAProteinHetionet hetionet:regulates:6240-7039Inferred only
TGFA decreases the expression of RUVBL1ProteinHetionet hetionet:regulates:7039-8607Inferred only
TGFA decreases the expression of SLC11A2ProteinHetionet hetionet:regulates:7039-4891Inferred only
TGFA decreases the expression of SLC25A46ProteinHetionet hetionet:regulates:7039-91137Inferred only
TGFA decreases the expression of SLC35B1ProteinHetionet hetionet:regulates:7039-10237Inferred only
TGFA decreases the expression of SMNDC1ProteinHetionet hetionet:regulates:7039-10285Inferred only
TGFA increases the expression of SNIP1ProteinHetionet hetionet:regulates:7039-79753Inferred only
TGFA increases the expression of SNX13ProteinHetionet hetionet:regulates:7039-23161Inferred only
TGFA decreases the expression of STXBP1ProteinHetionet hetionet:regulates:7039-6812Inferred only
TBK1 increases the expression of TGFAProteinHetionet hetionet:regulates:29110-7039Inferred only
TGFA increases the expression of TFIP11ProteinHetionet hetionet:regulates:7039-24144Inferred only
TGFA decreases the expression of TIMM17BProteinHetionet hetionet:regulates:7039-10245Inferred only
TGFA decreases the expression of TKTProteinHetionet hetionet:regulates:7039-7086Inferred only
TGFA increases the expression of TM9SF2ProteinHetionet hetionet:regulates:7039-9375Inferred only
TGFA decreases the expression of TMEM243ProteinHetionet hetionet:regulates:7039-79161Inferred only
TGFA decreases the expression of TYMSProteinHetionet hetionet:regulates:7039-7298Inferred only
TGFA decreases the expression of UGDHProteinHetionet hetionet:regulates:7039-7358Inferred only
TGFA increases the expression of WASF3ProteinHetionet hetionet:regulates:7039-10810Inferred only
TGFA increases the expression of WBP4ProteinHetionet hetionet:regulates:7039-11193Inferred only

Other names

5 names

Resolves to: TGFA

Also called: ]EGF-like TGFETGFTGF type 1TGF-alpha

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