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Proteins/UNIPROT:Q96PZ0
Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types..
Function from UniProtKB (Q96PZ0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
17 statements
17 statements · 3 reference databases · Subject: PUS7 · Sources: gene ontology, Hetionet, Reactome
3 reactions
CHEBI:65315CHEBI:65314
Catalysed by PUS7
Reaction pageDirection not assertedBalanced
Rhea RHEA:42540CC BY 4.0Reference data
a uridine in tRNAa pseudouridine in tRNA
Catalysed by RPUSD2 or TRUB1 or RPUSD4 or PUS7 or RPUSD1 or PUS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54572CC BY 4.0Reference data
a uridine in mRNA
2 names
Resolves to: PUS7
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56644CC BY 4.0Reference data