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Proteins/UNIPROT:Q7Z2E3
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)..
Function from UniProtKB (Q7Z2E3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
77 statements
77 statements · 4 reference databases · Subject: APTX · Sources: gene ontology, Hetionet, Human Protein Atlas, WikiPathways
3 reactions
a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA+watera 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA+AMP+2hydron
Catalysed by APTX
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:52128CC BY 4.0Reference data
a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA+watera 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA+AMP+2hydron
Catalysed by
3 names
Resolves to: APTX
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:52132CC BY 4.0Reference data
a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA+watera 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA+GMP+2hydron
Catalysed by APTX
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:52140CC BY 4.0Reference data