Loading the page.
Proteins/UNIPROT:Q99576
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities. In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity)..
[Isoform 1]: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG..
Function from UniProtKB (Q99576), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
225 statements
225 statements · 4 reference databases · Subject: TSC22D3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
10 names
Resolves to: TSC22D3