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Proteins/UNIPROT:P07196

NEFL

Protein·UNIPROT:P07196

Open in the graph

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)..

Function from UniProtKB (P07196), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

5 rows

Charcot-Marie-Tooth disease has a germline basis in NEFLDiseaseGenCC HGNC:7739|MONDO:0015626Inferred only
Charcot-Marie-Tooth disease type 1F has a germline basis in NEFLDiseaseGenCC HGNC:7739|MONDO:0011902Inferred only
Charcot-Marie-Tooth disease type 2 has a germline basis in NEFLDiseaseGenCC HGNC:7739|MONDO:0018993Inferred only
Charcot-Marie-Tooth disease type 2B5 has a germline basis in NEFLDiseaseGenCC HGNC:7739|MONDO:0016454Inferred only
Charcot-Marie-Tooth disease type 2E has a germline basis in NEFLDiseaseGenCC HGNC:7739|MONDO:0011894Inferred only

Statements

49 statements

49 statements · 4 reference databases · Subject: NEFL · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

NEFL covaries with TMEM145ProteinHetionet hetionet:covaries:284339-4747Inferred only
NEFL interacts with BRD7ProteinHetionet hetionet:interacts:29117-4747Inferred only
NEFL interacts with CDK5RAP2ProteinHetionet hetionet:interacts:4747-55755Inferred only
CHD3 interacts with NEFLProteinHetionet hetionet:interacts:1107-4747Inferred only
GRIN1 interacts with NEFLProteinHetionet hetionet:interacts:2902-4747Inferred only
NEFL interacts with HSPB3ProteinHetionet hetionet:interacts:4747-8988Inferred only
MAP2 interacts with NEFLProteinHetionet hetionet:interacts:4133-4747Inferred only
NEFL interacts with MTMR2ProteinHetionet hetionet:interacts:4747-8898Inferred only
MYO5A interacts with NEFLProteinHetionet hetionet:interacts:4644-4747Inferred only
NEFH interacts with NEFLProteinHetionet hetionet:interacts:4744-4747Inferred only
NEFL interacts with PIAS4ProteinHetionet hetionet:interacts:4747-51588Inferred only
NEFL interacts with PKN1ProteinHetionet hetionet:interacts:4747-5585Inferred only

Show the remaining 37

NEFL interacts with RANProteinHetionet hetionet:interacts:4747-5901Inferred only
NEFL interacts with SCHIP1ProteinHetionet hetionet:interacts:29970-4747Inferred only
NEFL interacts with SIRT7ProteinHetionet hetionet:interacts:4747-51547Inferred only
NEFL interacts with SPTAN1ProteinHetionet hetionet:interacts:4747-6709Inferred only
NEFL interacts with TERF1ProteinHetionet hetionet:interacts:4747-7013Inferred only
NEFL interacts with TNFProteinHetionet hetionet:interacts:4747-7124Inferred only
NEFL interacts with TSC1ProteinHetionet hetionet:interacts:4747-7248Inferred only
NEFL interacts with UBCProteinHetionet hetionet:interacts:4747-7316Inferred only
NEFL interacts with UBDProteinHetionet hetionet:interacts:10537-4747Inferred only
NEFL interacts with VIMProteinHetionet hetionet:interacts:4747-7431Inferred only
NEFL participates in Activation of NMDA receptors and postsynaptic eventsPathwayReactome R-HSA-442755Inferred only
NEFL participates in Amyotrophic lateral sclerosis ALS PathwayWikiPathways WP2447Inferred only
NEFL participates in Assembly and cell surface presentation of NMDA receptorsPathwayReactome R-HSA-9609736Inferred only
NEFL participates in Blood based neuroinflammation markers PathwayWikiPathways WP5548Inferred only
NEFL participates in Cell lineage map for neuronal differentiationPathwayWikiPathways WP5417Inferred only
NEFL participates in Ciliary landscapePathwayWikiPathways WP4352Inferred only
NEFL participates in CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signalingPathwayReactome R-HSA-442742Inferred only
NEFL participates in Intracellular trafficking proteins involved in CMT neuropathyPathwayWikiPathways WP4856Inferred only
NEFL participates in Long-term potentiationPathwayReactome R-HSA-9620244Inferred only
NEFL participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
NEFL participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
NEFL participates in Negative regulation of NMDA receptor-mediated neuronal transmissionPathwayReactome R-HSA-9617324Inferred only
NEFL participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
NEFL participates in Neurotransmitter receptors and postsynaptic signal transmissionPathwayReactome R-HSA-112314Inferred only
NEFL participates in NO cGMP PKG mediated neuroprotectionPathwayWikiPathways WP4008Inferred only
NEFL participates in Physico chemical features and toxicity associated pathwaysPathwayWikiPathways WP3680Inferred only
NEFL participates in Post NMDA receptor activation eventsPathwayReactome R-HSA-438064Inferred only
NEFL participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
NEFL participates in Ras activation upon Ca2+ influx through NMDA receptorPathwayReactome R-HSA-442982Inferred only
NEFL participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
NEFL participates in Transmission across Chemical SynapsesPathwayReactome R-HSA-112315Inferred only
NEFL participates in Unblocking of NMDA receptors, glutamate binding and activationPathwayReactome R-HSA-438066Inferred only
NEFL regulates regulation of synapse maturationBiological processgene ontology P07196|GO:0090128Inferred only
COG2 increases the expression of NEFLProteinHetionet hetionet:regulates:22796-4747Inferred only
NCOA3 increases the expression of NEFLProteinHetionet hetionet:regulates:8202-4747Inferred only
PSMB5 increases the expression of NEFLProteinHetionet hetionet:regulates:5693-4747Inferred only
PSMD3 increases the expression of NEFLProteinHetionet hetionet:regulates:5709-4747Inferred only

Other names

5 names

Resolves to: NEFL

Also called: 68 kDa neurofilament proteinNeurofilament triplet L proteinNF-LNF68NFL

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