Pathway
Metabolism of water-soluble vitamins and cofactors
Vitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only in limited amounts by human cells. Vitamins are classified according to their solubility, either fat-soluble or water-soluble. The physiological processes dependent on vitamin-requiring reactions include many aspects of intermediary metabolism, vision, bone formation, and blood coagulation, and vitamin deficiencies are associated with a correspondingly diverse and severe group of diseases.
Continue reading
Water-soluble vitamins include ascorbate (vitamin C) and the members of the B group: thiamin (vitamin B1), riboflavin (B2), niacin (B3), pantothenate (B5), pyridoxine (B6), biotin (B7), folate (B9), and cobalamin (B12). Metabolic processes annotated here include the synthesis of thiamin pyrophosphate (TPP) from thiamin (B1), the synthesis of FMN and FAD from riboflavin (B2), the synthesis of nicotinic acid (niacin - B3) from tryptophan, the synthesis of Coenzyme A from pantothenate (B5), features of the metabolism of folate (B9), the uptake, transport, and metabolism of cobalamin (B12), and molybdenum cofactor biosynthesis.
REACT:R-HSA-196849Reactome
What the reference databases state
Statements
122 statements
122 statements · 1 reference database · Subject: Metabolism of water-soluble vitamins and cofactors · Sources: Reactome
- AASDHPPT participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- ABCC1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- ABCD4 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- ACACA participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- ACACB participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- ACP5 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- ALDH1L1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- ALDH1L2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- AMN participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- AOX1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- BST1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- BTD participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
Show the remaining 110
- CBLIF participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- CD320 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- CD38 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- COASY participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- CTRB1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- CTRB2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- CUBN participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- CYB5A participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- CYB5R3 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- DCAKD participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- DHFR participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- DHFR2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- ENPP1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- ENPP2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- ENPP3 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- FASN participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- FLAD1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- FOLR2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- GPHN participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- GSTO1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- GSTO2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- HLCS participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- LDLRAP1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- LMBRD1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- LRP2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MCCC1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MCCC2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MMAA participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MMAB participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MMACHC participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MMADHC participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MMUT participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MOCOS participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MOCS2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MOCS3 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MTHFD1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MTHFD1L participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MTHFD2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MTHFD2L participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MTHFR participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MTHFS participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MTR participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- MTRR participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NADK participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NADK2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NADSYN1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NAMPT participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NAPRT participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NAXD participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NAXE participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NMNAT1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NMNAT2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NMNAT3 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NMRK1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NMRK2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NNMT participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NT5E participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NUDT12 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- NUDT8 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PANK1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PANK2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PANK3 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PANK4 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PARP10 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PARP14 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PARP16 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PARP4 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PARP6 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PARP8 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PARP9 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PC participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PCCA participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PCCB participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PDXK participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PDZD11 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PNPO participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PPCDC participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PPCS participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PRSS1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- PRSS3 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- QPRT participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- RFK participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- RNLS participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SHMT1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SHMT2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC19A1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC19A2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC19A3 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC22A13 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC23A1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC23A2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC25A16 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC25A19 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC25A32 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC25A42 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC25A51 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC2A1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC2A3 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC46A1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC52A1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC52A2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC52A3 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC5A6 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- SLC5A8 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- TCN1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- TCN2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- THTPA participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- TPK1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- VNN1 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only
- VNN2 participates in Metabolism of water-soluble vitamins and cofactorsProteinReactome R-HSA-196849Inferred only