Proteins/UNIPROT:P35680

HNF1B

ProteinUNIPROT:P35680

Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1..

Function from UniProtKB (P35680), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

8 rows

medullary sponge kidney has a germline basis in HNF1BDiseaseGenCC HGNC:11630|MONDO:0015268Inferred only
permanent neonatal diabetes mellitus has a germline basis in HNF1BDiseaseGenCC HGNC:11630|MONDO:0100164Inferred only
renal cysts and diabetes syndrome has a germline basis in HNF1BDiseaseGenCC HGNC:11630|MONDO:0007669Inferred only
renal dysplasia, bilateral has a germline basis in HNF1BDiseaseGenCC HGNC:11630|MONDO:0019645Inferred only
renal dysplasia, unilateral has a germline basis in HNF1BDiseaseGenCC HGNC:11630|MONDO:0019644Inferred only
transient neonatal diabetes mellitus has a germline basis in HNF1BDiseaseGenCC HGNC:11630|MONDO:0020525Inferred only
type 2 diabetes mellitus has a germline basis in HNF1BDiseaseGenCC HGNC:11630|MONDO:0005148Inferred only
unilateral multicystic dysplastic kidney has a germline basis in HNF1BDiseaseGenCC HGNC:11630|MONDO:0019981Inferred only

Statements

92 statements

92 statements · 4 reference databases · Subject: HNF1B · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

SLC52A2 covaries with HNF1BProteinHetionet hetionet:covaries:6928-79581Inferred only
TMEM229A covaries with HNF1BProteinHetionet hetionet:covaries:6928-730130Inferred only
ATF1 interacts with HNF1BProteinHetionet hetionet:interacts:466-6928Inferred only
HNF1B interacts with H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12ProteinHetionet hetionet:interacts:6928-8351Inferred only
HNF1B interacts with H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12ProteinHetionet hetionet:interacts:6928-8353Inferred only
HNF1B interacts with H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12ProteinHetionet hetionet:interacts:6928-8352Inferred only
HNF1B interacts with H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12ProteinHetionet hetionet:interacts:6928-8355Inferred only
HNF1B interacts with H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12ProteinHetionet hetionet:interacts:6928-8357Inferred only
HNF1B interacts with H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12ProteinHetionet hetionet:interacts:6928-8968Inferred only
HNF1B interacts with H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12ProteinHetionet hetionet:interacts:6928-8350Inferred only
HNF1B interacts with H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12ProteinHetionet hetionet:interacts:6928-8356Inferred only
HNF1B interacts with H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12ProteinHetionet hetionet:interacts:6928-8358Inferred only

Show the remaining 80

HNF1B interacts with H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12ProteinHetionet hetionet:interacts:6928-8354Inferred only
HNF1A interacts with HNF1BProteinHetionet hetionet:interacts:6927-6928Inferred only
PCBD1 interacts with HNF1BProteinHetionet hetionet:interacts:5092-6928Inferred only
HNF1B participates in 17q12 copy number variation syndromePathwayWikiPathways WP5287Inferred only
HNF1B participates in Circadian rhythm genesPathwayWikiPathways WP3594Inferred only
HNF1B participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
HNF1B participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
HNF1B participates in Developmental Cell Lineages of the Exocrine PancreasPathwayReactome R-HSA-9820448Inferred only
HNF1B participates in Developmental Lineage of Multipotent Pancreatic Progenitor CellsPathwayReactome R-HSA-9937080Inferred only
HNF1B participates in Developmental Lineage of Pancreatic Acinar CellsPathwayReactome R-HSA-9925561Inferred only
HNF1B participates in Developmental Lineage of Pancreatic Ductal CellsPathwayReactome R-HSA-9925563Inferred only
HNF1B participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
HNF1B participates in GDNF RET signaling axisPathwayWikiPathways WP4830Inferred only
HNF1B participates in Genes controlling nephrogenesisPathwayWikiPathways WP4823Inferred only
HNF1B participates in Kidney developmentPathwayReactome R-HSA-9830369Inferred only
HNF1B participates in Markers of kidney cell lineagePathwayWikiPathways WP5236Inferred only
HNF1B participates in Nephron developmentPathwayReactome R-HSA-9831926Inferred only
HNF1B participates in Regulation of beta-cell developmentPathwayReactome R-HSA-186712Inferred only
HNF1B participates in Regulation of gene expression in early pancreatic precursor cellsPathwayReactome R-HSA-210747Inferred only
HNF1B participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsPathwayReactome R-HSA-210744Inferred only
HNF1B regulates positive regulation of DNA-templated transcriptionBiological processgene ontology P35680|GO:0045893Inferred only
HNF1B regulates positive regulation of transcription initiation by RNA polymerase IIBiological processgene ontology P35680|GO:0060261Inferred only
HNF1B regulates regulation of pronephros sizeBiological processgene ontology P35680|GO:0035565Inferred only
HNF1B regulates regulation of transcription by RNA polymerase IIBiological processgene ontology P35680|GO:0006357Inferred only
HNF1B decreases the expression of ABCB6ProteinHetionet hetionet:regulates:6928-10058Inferred only
HNF1B decreases the expression of AKT1ProteinHetionet hetionet:regulates:6928-207Inferred only
ALPK1 increases the expression of HNF1BProteinHetionet hetionet:regulates:80216-6928Inferred only
HNF1B decreases the expression of CASC3ProteinHetionet hetionet:regulates:6928-22794Inferred only
HNF1B increases the expression of CCDC92ProteinHetionet hetionet:regulates:6928-80212Inferred only
HNF1B decreases the expression of CCN1ProteinHetionet hetionet:regulates:6928-3491Inferred only
HNF1B decreases the expression of CDC20ProteinHetionet hetionet:regulates:6928-991Inferred only
HNF1B increases the expression of CDK5R1ProteinHetionet hetionet:regulates:6928-8851Inferred only
HNF1B increases the expression of CES1ProteinHetionet hetionet:regulates:6928-1066Inferred only
HNF1B decreases the expression of CHERPProteinHetionet hetionet:regulates:6928-10523Inferred only
HNF1B increases the expression of CPVLProteinHetionet hetionet:regulates:6928-54504Inferred only
HNF1B increases the expression of CSNK1EProteinHetionet hetionet:regulates:6928-1454Inferred only
HNF1B decreases the expression of DPH2ProteinHetionet hetionet:regulates:6928-1802Inferred only
HNF1B decreases the expression of DUSP14ProteinHetionet hetionet:regulates:6928-11072Inferred only
HNF1B decreases the expression of ERBB2ProteinHetionet hetionet:regulates:6928-2064Inferred only
HNF1B increases the expression of FAIMProteinHetionet hetionet:regulates:6928-55179Inferred only
HNF1B increases the expression of FIS1ProteinHetionet hetionet:regulates:6928-51024Inferred only
HNF1B decreases the expression of G3BP1ProteinHetionet hetionet:regulates:6928-10146Inferred only
HNF1B decreases the expression of GCDHProteinHetionet hetionet:regulates:6928-2639Inferred only
HNF1B decreases the expression of GNAI2ProteinHetionet hetionet:regulates:6928-2771Inferred only
HNF1B increases the expression of GNPDA1ProteinHetionet hetionet:regulates:6928-10007Inferred only
GTF2E2 decreases the expression of HNF1BProteinHetionet hetionet:regulates:2961-6928Inferred only
HNF1B decreases the expression of HDAC2ProteinHetionet hetionet:regulates:6928-3066Inferred only
HNF1B decreases the expression of HDGFL3ProteinHetionet hetionet:regulates:6928-50810Inferred only
HNF1B decreases the expression of HMG20BProteinHetionet hetionet:regulates:6928-10362Inferred only
HNF1B increases the expression of IKBKBProteinHetionet hetionet:regulates:6928-3551Inferred only
HNF1B decreases the expression of KIF20AProteinHetionet hetionet:regulates:6928-10112Inferred only
HNF1B increases the expression of MALProteinHetionet hetionet:regulates:6928-4118Inferred only
HNF1B decreases the expression of MAPKAPK2ProteinHetionet hetionet:regulates:6928-9261Inferred only
HNF1B decreases the expression of MTHFD2ProteinHetionet hetionet:regulates:6928-10797Inferred only
HNF1B decreases the expression of MYCProteinHetionet hetionet:regulates:6928-4609Inferred only
HNF1B increases the expression of NCK2ProteinHetionet hetionet:regulates:6928-8440Inferred only
HNF1B decreases the expression of PAGR1ProteinHetionet hetionet:regulates:6928-79447Inferred only
PCBD1 decreases the expression of HNF1BProteinHetionet hetionet:regulates:5092-6928Inferred only
HNF1B decreases the expression of PCNAProteinHetionet hetionet:regulates:6928-5111Inferred only
HNF1B increases the expression of PECRProteinHetionet hetionet:regulates:6928-55825Inferred only
HNF1B decreases the expression of PKN1ProteinHetionet hetionet:regulates:6928-5585Inferred only
PLPP1 decreases the expression of HNF1BProteinHetionet hetionet:regulates:8611-6928Inferred only
HNF1B decreases the expression of PNPProteinHetionet hetionet:regulates:6928-4860Inferred only
HNF1B decreases the expression of PPP2R5EProteinHetionet hetionet:regulates:6928-5529Inferred only
HNF1B decreases the expression of PSIP1ProteinHetionet hetionet:regulates:6928-11168Inferred only
HNF1B decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:6928-6192Inferred only
HNF1B increases the expression of RRP8ProteinHetionet hetionet:regulates:6928-23378Inferred only
HNF1B increases the expression of SERPINA3ProteinHetionet hetionet:regulates:6928-12Inferred only
HNF1B decreases the expression of SKIC2ProteinHetionet hetionet:regulates:6928-6499Inferred only
HNF1B decreases the expression of SMARCD2ProteinHetionet hetionet:regulates:6928-6603Inferred only
HNF1B increases the expression of ST6GALNAC2ProteinHetionet hetionet:regulates:6928-10610Inferred only
HNF1B decreases the expression of STMN1ProteinHetionet hetionet:regulates:6928-3925Inferred only
HNF1B decreases the expression of STUB1ProteinHetionet hetionet:regulates:6928-10273Inferred only
HNF1B decreases the expression of TBPProteinHetionet hetionet:regulates:6928-6908Inferred only
HNF1B decreases the expression of TIMELESSProteinHetionet hetionet:regulates:6928-8914Inferred only
HNF1B decreases the expression of TSC2ProteinHetionet hetionet:regulates:6928-7249Inferred only
HNF1B decreases the expression of TSPAN4ProteinHetionet hetionet:regulates:6928-7106Inferred only
HNF1B decreases the expression of TYK2ProteinHetionet hetionet:regulates:6928-7297Inferred only
HNF1B increases the expression of USP9XProteinHetionet hetionet:regulates:6928-8239Inferred only
HNF1B increases the expression of WFS1ProteinHetionet hetionet:regulates:6928-7466Inferred only

Other names

8 names

Resolves to: HNF1B

Also called: HNF-1-betaHNF-1BHomeoprotein LFB3TCF-2TCF2Transcription factor 2Variant hepatic nuclear factor 1vHNF1

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