Proteins/UNIPROT:Q9Y3M2

CBY1

ProteinUNIPROT:Q9Y3M2

Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation (By similarity)..

Function from UniProtKB (Q9Y3M2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

ciliopathy has a germline basis in CBY1DiseaseGenCC HGNC:1307|MONDO:0005308Inferred only
Joubert syndrome has a germline basis in CBY1DiseaseGenCC HGNC:1307|MONDO:0018772Inferred only

Statements

24 statements

24 statements · 4 reference databases · Subject: CBY1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CBY1 covaries with ANGPT4ProteinHetionet hetionet:covaries:25776-51378Inferred only
AGTPBP1 interacts with CBY1ProteinHetionet hetionet:interacts:23287-25776Inferred only
CDK6 interacts with CBY1ProteinHetionet hetionet:interacts:1021-25776Inferred only
CLU interacts with CBY1ProteinHetionet hetionet:interacts:1191-25776Inferred only
CTNNB1 interacts with CBY1ProteinHetionet hetionet:interacts:1499-25776Inferred only
CBY1 interacts with NBPF11ProteinHetionet hetionet:interacts:200030-25776Inferred only
CBY1 participates in Deactivation of the beta-catenin transactivating complexPathwayReactome R-HSA-3769402Inferred only
CBY1 participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only
CBY1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CBY1 participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
CBY1 participates in TCF dependent signaling in response to WNTPathwayReactome R-HSA-201681Inferred only
CBY1 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q9Y3M2|GO:0045892Inferred only

Show the remaining 12

CBY1 regulates negative regulation of Wnt signaling pathwayBiological processgene ontology Q9Y3M2|GO:0030178Inferred only
ACAA1 decreases the expression of CBY1ProteinHetionet hetionet:regulates:30-25776Inferred only
AFF4 increases the expression of CBY1ProteinHetionet hetionet:regulates:27125-25776Inferred only
CHCHD7 increases the expression of CBY1ProteinHetionet hetionet:regulates:79145-25776Inferred only
FASLG increases the expression of CBY1ProteinHetionet hetionet:regulates:356-25776Inferred only
FOXJ1 increases the expression of CBY1ProteinHetionet hetionet:regulates:2302-25776Inferred only
MTHFD2 increases the expression of CBY1ProteinHetionet hetionet:regulates:10797-25776Inferred only
P4HA1 increases the expression of CBY1ProteinHetionet hetionet:regulates:5033-25776Inferred only
PDPK1 increases the expression of CBY1ProteinHetionet hetionet:regulates:5170-25776Inferred only
PLEKHJ1 increases the expression of CBY1ProteinHetionet hetionet:regulates:55111-25776Inferred only
RPS14 increases the expression of CBY1ProteinHetionet hetionet:regulates:6208-25776Inferred only
SRF decreases the expression of CBY1ProteinHetionet hetionet:regulates:6722-25776Inferred only

Other names

8 names

Resolves to: CBY1

Also called: ARB1ARPP-binding proteinC22orf2CBYCytosolic leucine-rich proteinPGEA1PIGEA-14PKD2 interactor, Golgi and endoplasmic reticulum-associated 1

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