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Proteins/UNIPROT:P55263
Adenosine kinase that mediates the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner: catalyzes phosphorylation of both unmodified and modified adenosines. Plays a key role in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification. Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction. Catalyzes the phosphorylation of the free cytosolic methylated adenosine nucleotides N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) into adenosine monophosphate (AMP) intermediates that are further detoxified by MAPDA/ADAL..
Function from UniProtKB (P55263), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
43 statements
43 statements · 7 reference databases · Subject: ADK · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
5 names
Resolves to: ADK
Reaction pageLeft to rightBalancedEC 2.7.1.20mitochondrial matrix
Human-GEM MAR04083CC BY 4.0Reference data
adenosine+ATP(4-)AMP+ADP(3-)+hydron
Catalysed by ADK
Reaction pageLeft to rightBalanced
Rhea RHEA:20824CC BY 4.0Reference data
N(6)-methyladenosine+ATP(4-)N(6)-methyl-AMP+ADP(3-)+hydron
Catalysed by ADK
Reaction pageLeft to rightBalanced
Rhea RHEA:86211CC BY 4.0Reference data
N(6),N(6)-dimethyladenosine+ATP(4-)N(6),N(6)-dimethyl-AMP+ADP(3-)+hydron
Catalysed by ADK
Reaction pageLeft to rightBalanced
Rhea RHEA:86215CC BY 4.0Reference data
CHEBI:62881+ATP(4-)N(6)-(dimethylallyl)adenosine 5'-phosphate+ADP(3-)+hydron
Catalysed by ADK
Reaction pageLeft to rightBalanced
Rhea RHEA:86219CC BY 4.0Reference data