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Proteins/UNIPROT:Q9Y663
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate..
Function from UniProtKB (Q9Y663), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
24 statements
24 statements · 3 reference databases · Subject: HS3ST3A1 · Sources: Hetionet, Reactome, WikiPathways
2 reactions
MAM02087g+3'-phospho-5'-adenylyl sulfateproton+MAM02054g+adenosine 3',5'-bismonophosphate
Catalysed by HS3ST1 or HS3ST3B1 or HS3ST3A1 or HS3ST6 or HS3ST4 or HS3ST5
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.23, 2.8.2.30Golgi apparatus
Human-GEM MAR07222CC BY 4.0Reference data
alpha-D-glucosaminyl-[heparan sulfate](n)+3'-phosphoadenylyl sulfate
6 names
Resolves to: HS3ST3A1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15461CC BY 4.0Reference data