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Proteins/UNIPROT:O15511
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)..
Function from UniProtKB (O15511), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
77 statements
77 statements · 4 reference databases · Subject: ARPC5 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
3 names
Resolves to: ARPC5