RAC2 GTPase cycle

This pathway catalogues RAC2 guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RAC2 effectors. RAC2 is exclusively expressed in hematopoietic cells. RAC2 is a component of the phagocytic oxidase complex in neutrophils. RAC2 is required for adhesion and mobilization of hematopoietic stem cells and progenitor cells. RAC2 is also needed for adhesion, migration and degranulation of mast cells. Mutations in RAC2 have been found in a small number of patients with primary immunodeficiencies.

Summary from Reactome (R-HSA-9013404), read 2026-09-23.