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Proteins/UNIPROT:O60516
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export..
Function from UniProtKB (O60516), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
32 statements
32 statements · 3 reference databases · Subject: EIF4EBP3 · Sources: gene ontology, Hetionet, WikiPathways
2 names
Resolves to: EIF4EBP3