Pathway
RHOC GTPase cycle
This pathway catalogues RHOC guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOC effectors. RHOC belongs to the RHOA subfamily of RHO GTPases and shares 85% sequence identity with RHOA and RHOB. Like RHOA and RHOB, RHOC regulates the cytoskeleton and is involved in cell adhesion and migration. RHOC contributes to invasiveness and metastatic potential of cancer cells.
REACT:R-HSA-9013106Reactome
What the reference databases state
Statements
71 statements
71 statements · 1 reference database · Subject: RHOC GTPase cycle · Sources: Reactome
- ABCD3 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ABR participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ACBD5 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- AKAP13 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ANLN participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGAP1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGAP18 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGAP21 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGAP26 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGAP32 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGAP35 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGAP5 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
Show the remaining 59
- ARHGDIA participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGEF1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGEF10 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGEF10L participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGEF11 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGEF12 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGEF17 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGEF25 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGEF28 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGEF40 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ARHGEF5 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- BCR participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- C1QBP participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- CAV1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- CAVIN1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- CIT participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- DAAM1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- DEPDC1B participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- DIAPH1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- DIAPH3 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- DLC1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ERBIN participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- FLOT1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- FLOT2 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- FMNL2 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- FMNL3 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- IQGAP1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- IQGAP3 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- JUP participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- LBR participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- LMAN1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- MACO1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- MCAM participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- MCF2 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- MCF2L participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- MYO9B participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- OPHN1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- PIK3R1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- PKN1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- PKN2 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- PKN3 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- PREX1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- RACGAP1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- RHOA participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- RHOC participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ROCK1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- ROCK2 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- RTKN participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- SLK participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- STARD13 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- STK10 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- STOM participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- STX5 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- TFRC participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- TJP2 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- VAMP3 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- VANGL1 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- VAPB participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only
- VAV2 participates in RHOC GTPase cycleProteinReactome R-HSA-9013106Inferred only