Pathway
RHOA GTPase cycle
This pathway catalogues RHOA guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOA effectors. RHOA is one of the three best characterized RHO GTPases, the other two being RAC1 and CDC42, and is the founding member of the RHO GTPase family. RHOA regulates the cytoskeleton and cell contractility, thus playing a role in a number of cellular functions, such as adhesion, migration, survival, division, vesicle trafficking and gene expression. RHOA-regulated processes are involved in mechanotransduction, neuronal development, immune system development, and cardiovascular regulation. RHOA mutations are frequently found in cancer. Toxins of numerous pathogens target RHOA to hijack the host cytoskeleton.
REACT:R-HSA-8980692Reactome
What the reference databases state
Statements
145 statements
145 statements · 1 reference database · Subject: RHOA GTPase cycle · Sources: Reactome
- AAAS participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ABCD3 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ABR participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ACBD5 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ACTC1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- AKAP13 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ANLN participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARAP1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARAP2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARAP3 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP10 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
Show the remaining 133
- ARHGAP11A participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP18 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP19 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP20 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP21 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP22 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP23 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP24 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP26 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP28 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP29 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP30 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP31 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP32 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP35 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP4 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP40 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP42 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP44 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP45 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP5 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP6 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP8 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGAP9 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGDIA participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGDIB participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF10 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF10L participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF11 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF12 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF15 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF17 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF18 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF19 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF25 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF28 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF3 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF4 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF40 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF5 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ARHGEF7 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ATP6AP1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- BCAP31 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- BCR participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- C1QBP participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- CAV1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- CAVIN1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- CIT participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- DAAM1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- DDRGK1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- DEF6 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- DEPDC1B participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- DIAPH1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- DIAPH3 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- DLC1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- DOCK2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ECT2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- EMC3 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ERBIN participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- FAF2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- FAM13A participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- FARP1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- FLOT1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- FLOT2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- FMNL3 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- GMIP participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- HMOX2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- IQGAP1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- IQGAP3 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- JUP participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- KALRN participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- KTN1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- LBR participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- LMAN1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- MACO1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- MCAM participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- MCF2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- MCF2L participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- MYO9A participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- MYO9B participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- NET1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- NGEF participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- OPHN1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PCDH7 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PGRMC2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PIK3R1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PIK3R2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PKN1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PKN2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PKN3 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PLD1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PLEKHG3 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PLEKHG4 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PLEKHG5 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PLEKHG6 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PREX1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- PREX2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- RACGAP1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- RASGRF2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- RHOA participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- RHPN1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- RHPN2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ROCK1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- ROCK2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- RTKN participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- SCFD1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- SLK participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- SNAP23 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- SOWAHC participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- SRGAP1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- STARD13 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- STARD8 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- STBD1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- STK10 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- STOM participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- STX5 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- TAGAP participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- TEX2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- TFRC participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- TIAM1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- TJP2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- TMEM87A participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- TRIO participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- VAMP3 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- VANGL1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- VAPB participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- VAV1 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- VAV2 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- VAV3 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- VMA22 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only
- YKT6 participates in RHOA GTPase cycleProteinReactome R-HSA-8980692Inferred only