Mitotic Metaphase and Anaphase

The metaphase to anaphase transition during mitosis is triggered by the destruction of mitotic cyclins.

In anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement along the spindle microtubules and through the physical interaction of polar microtubules.