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Proteins/UNIPROT:Q9Y5L3
Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs), with a marked preference for triphosphonucleosides over diphosphonucleosides. The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates. This activity contributes to the regulation of extracellular nucleotides levels. ATP hydrolysis is characterized by fast ADP accumulation and delayed AMP formation, reflecting limited ADP hydrolase activity (By similarity). Hydrolyzes ADP and UDP only to a marginal extent, and does not hydrolyze AMP. All nucleoside 5'-diphosphates are hydrolyzed at rates lower than those of their corresponding triphosphates (By similarity)..
[Isoform gamma]: Catalytically inactive..
[Isoform Short]: Catalytically inactive..
Function from UniProtKB (Q9Y5L3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
22 statements
22 statements · 5 reference databases · Subject: ENTPD2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt
25 reactions
ADP+waterAMP+proton+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6cytosol
Human-GEM MAR03998CC BY 4.0Reference data
7 names
Resolves to: ENTPD2
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6endoplasmic reticulum
Human-GEM MAR04059CC BY 4.0Reference data
water+UDPproton+phosphate(3-)+UMP
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6extracellular space
Human-GEM MAR04060CC BY 4.0Reference data
GDP+waterGMP+proton+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6, 3.6.1.42extracellular space
Human-GEM MAR04134CC BY 4.0Reference data
GTP+waterGDP+proton+phosphate(3-)
Catalysed by ENTPD2 or DNM2 or DNM1L or DNM1 or ENTPD1 or EFL1 or EEF1A1 or GFM2 or EEF2 or ENTPD3 or GFM1 or CANT1 and 5 more alternatives
Reaction pageLeft to rightBalancedEC 3.6.5.1, 3.6.5.2, 3.6.5.3, 3.6.5.4, 3.6.5.5, 3.6.5.6extracellular space
Human-GEM MAR04136CC BY 4.0Reference data
water+CHEBI:17808proton+CHEBI:17202+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6extracellular space
Human-GEM MAR04342CC BY 4.0Reference data
ATP+2waterAMP+2proton+2phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6, 3.6.1.42extracellular space
Human-GEM MAR08474CC BY 4.0Reference data
ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:13065CC BY 4.0Reference data
GTP+waterGDP+hydrogenphosphate+hydron
Catalysed by IRGM or RAB19 or TUBAL3 or GTPBP1 or RAB27B or RHOD or DNM1L or MRAS or RAB29 or OPA1 or EIF5B or ENTPD3 and 183 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:19669CC BY 4.0Reference data
ATP(4-)+2waterAMP+2hydrogenphosphate+2hydron
Catalysed by ENTPD3 or ENTPD1 or ENTPD8 or ENTPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:20988CC BY 4.0Reference data
GDP+waterGMP+hydrogenphosphate+hydron
Catalysed by ENTPD6 or ENTPD3 or ENTPD5 or GBP1 or ENTPD1 or GBP7 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:22156CC BY 4.0Reference data
a ribonucleoside 5'-triphosphate+watera ribonucleoside 5'-diphosphate+hydrogenphosphate+hydron
Catalysed by ENTPD3 or ENTPD1 or ENTPD8 or SMPDL3A or NTPCR or ENTPD7 or DDX20 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:23680CC BY 4.0Reference data