Proteins/UNIPROT:Q10570

CPSF1

ProteinUNIPROT:Q10570

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity)..

Function from UniProtKB (Q10570), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

myopia 27 has a germline basis in CPSF1DiseaseGenCC HGNC:2324|MONDO:0032941Inferred only

Statements

67 statements

67 statements · 3 reference databases · Subject: CPSF1 · Sources: Hetionet, Reactome, WikiPathways

Order

KRTAP4-8 covaries with CPSF1ProteinHetionet hetionet:covaries:29894-728224Inferred only
COPS6 interacts with CPSF1ProteinHetionet hetionet:interacts:10980-29894Inferred only
CSTF3 interacts with CPSF1ProteinHetionet hetionet:interacts:1479-29894Inferred only
CUL3 interacts with CPSF1ProteinHetionet hetionet:interacts:29894-8452Inferred only
CPSF1 interacts with GLIS2ProteinHetionet hetionet:interacts:29894-84662Inferred only
MCM2 interacts with CPSF1ProteinHetionet hetionet:interacts:29894-4171Inferred only
NPM1 interacts with CPSF1ProteinHetionet hetionet:interacts:29894-4869Inferred only
PAPOLA interacts with CPSF1ProteinHetionet hetionet:interacts:10914-29894Inferred only
PCLAF interacts with CPSF1ProteinHetionet hetionet:interacts:29894-9768Inferred only
POLR2A interacts with CPSF1ProteinHetionet hetionet:interacts:29894-5430Inferred only
PRRC2A interacts with CPSF1ProteinHetionet hetionet:interacts:29894-7916Inferred only
RRAGA interacts with CPSF1ProteinHetionet hetionet:interacts:10670-29894Inferred only

Show the remaining 55

CPSF1 interacts with SIRT7ProteinHetionet hetionet:interacts:29894-51547Inferred only
TAF11 interacts with CPSF1ProteinHetionet hetionet:interacts:29894-6882Inferred only
TAF12 interacts with CPSF1ProteinHetionet hetionet:interacts:29894-6883Inferred only
TAF13 interacts with CPSF1ProteinHetionet hetionet:interacts:29894-6884Inferred only
TAF5 interacts with CPSF1ProteinHetionet hetionet:interacts:29894-6877Inferred only
TAF7 interacts with CPSF1ProteinHetionet hetionet:interacts:29894-6879Inferred only
UBC interacts with CPSF1ProteinHetionet hetionet:interacts:29894-7316Inferred only
CPSF1 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
CPSF1 participates in Dengue Virus-Host InteractionsPathwayReactome R-HSA-9918481Inferred only
CPSF1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
CPSF1 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
CPSF1 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
CPSF1 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
CPSF1 participates in mRNA 3'-end processingPathwayReactome R-HSA-72187Inferred only
CPSF1 participates in mRNA PolyadenylationPathwayReactome R-HSA-9770562Inferred only
CPSF1 participates in mRNA processingPathwayWikiPathways WP411Inferred only
CPSF1 participates in Processing of Capped Intron-Containing Pre-mRNAPathwayReactome R-HSA-72203Inferred only
CPSF1 participates in Processing of Capped Intronless Pre-mRNAPathwayReactome R-HSA-75067Inferred only
CPSF1 participates in Processing of Intronless Pre-mRNAsPathwayReactome R-HSA-77595Inferred only
CPSF1 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
CPSF1 participates in RNA Polymerase II Transcription TerminationPathwayReactome R-HSA-73856Inferred only
CPSF1 participates in Transport of Mature mRNA Derived from an Intronless TranscriptPathwayReactome R-HSA-159231Inferred only
CPSF1 participates in Transport of Mature mRNAs Derived from Intronless TranscriptsPathwayReactome R-HSA-159234Inferred only
CPSF1 participates in Transport of Mature Transcript to CytoplasmPathwayReactome R-HSA-72202Inferred only
CPSF1 participates in tRNA processingPathwayReactome R-HSA-72306Inferred only
CPSF1 participates in tRNA processing in the nucleusPathwayReactome R-HSA-6784531Inferred only
CPSF1 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
ABCB5 decreases the expression of CPSF1ProteinHetionet hetionet:regulates:340273-29894Inferred only
CPSF1 increases the expression of AGR2ProteinHetionet hetionet:regulates:29894-10551Inferred only
ALDH3B1 decreases the expression of CPSF1ProteinHetionet hetionet:regulates:221-29894Inferred only
ASL increases the expression of CPSF1ProteinHetionet hetionet:regulates:435-29894Inferred only
ATP2C1 decreases the expression of CPSF1ProteinHetionet hetionet:regulates:27032-29894Inferred only
CPSF1 increases the expression of BAG3ProteinHetionet hetionet:regulates:29894-9531Inferred only
CANT1 decreases the expression of CPSF1ProteinHetionet hetionet:regulates:124583-29894Inferred only
CPSF1 increases the expression of DNAJB1ProteinHetionet hetionet:regulates:29894-3337Inferred only
ENTPD6 decreases the expression of CPSF1ProteinHetionet hetionet:regulates:955-29894Inferred only
GFUS decreases the expression of CPSF1ProteinHetionet hetionet:regulates:7264-29894Inferred only
CPSF1 increases the expression of HSPA1AProteinHetionet hetionet:regulates:29894-3303Inferred only
CPSF1 increases the expression of HSPA8ProteinHetionet hetionet:regulates:29894-3312Inferred only
CPSF1 increases the expression of HSPB1ProteinHetionet hetionet:regulates:29894-3315Inferred only
CPSF1 increases the expression of HSPH1ProteinHetionet hetionet:regulates:29894-10808Inferred only
L3MBTL4 decreases the expression of CPSF1ProteinHetionet hetionet:regulates:91133-29894Inferred only
CPSF1 increases the expression of MALProteinHetionet hetionet:regulates:29894-4118Inferred only
MECP2 decreases the expression of CPSF1ProteinHetionet hetionet:regulates:4204-29894Inferred only
MGMT decreases the expression of CPSF1ProteinHetionet hetionet:regulates:4255-29894Inferred only
NT5E decreases the expression of CPSF1ProteinHetionet hetionet:regulates:4907-29894Inferred only
CPSF1 increases the expression of P4HA2ProteinHetionet hetionet:regulates:29894-8974Inferred only
PANK4 decreases the expression of CPSF1ProteinHetionet hetionet:regulates:55229-29894Inferred only
CPSF1 decreases the expression of PCNAProteinHetionet hetionet:regulates:29894-5111Inferred only
PEPD decreases the expression of CPSF1ProteinHetionet hetionet:regulates:5184-29894Inferred only
PUF60 decreases the expression of CPSF1ProteinHetionet hetionet:regulates:22827-29894Inferred only
CPSF1 decreases the expression of RNF167ProteinHetionet hetionet:regulates:29894-26001Inferred only
RPA1 decreases the expression of CPSF1ProteinHetionet hetionet:regulates:6117-29894Inferred only
SOCS1 decreases the expression of CPSF1ProteinHetionet hetionet:regulates:8651-29894Inferred only
VPS28 decreases the expression of CPSF1ProteinHetionet hetionet:regulates:51160-29894Inferred only

Other names

3 names

Resolves to: CPSF1

Also called: Cleavage and polyadenylation specificity factor 160 kDa subunitCPSF 160 kDa subunitCPSF160

← Every protein Find it in the graph →