Proteins/UNIPROT:O43292

GPAA1

ProteinUNIPROT:O43292

Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds GPI-anchor..

Function from UniProtKB (O43292), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

glycosylphosphatidylinositol biosynthesis defect 15 has a germline basis in GPAA1DiseaseGenCC HGNC:4446|MONDO:0060627Inferred only

Statements

27 statements

27 statements · 3 reference databases · Subject: GPAA1 · Sources: Hetionet, Reactome, WikiPathways

Order

EIF3E interacts with GPAA1ProteinHetionet hetionet:interacts:3646-8733Inferred only
GRIK5 interacts with GPAA1ProteinHetionet hetionet:interacts:2901-8733Inferred only
GPAA1 interacts with PIGKProteinHetionet hetionet:interacts:10026-8733Inferred only
GPAA1 interacts with PIGTProteinHetionet hetionet:interacts:51604-8733Inferred only
GPAA1 interacts with PIGUProteinHetionet hetionet:interacts:128869-8733Inferred only
PIN1 interacts with GPAA1ProteinHetionet hetionet:interacts:5300-8733Inferred only
GPAA1 interacts with PRR13ProteinHetionet hetionet:interacts:54458-8733Inferred only
UBC interacts with GPAA1ProteinHetionet hetionet:interacts:7316-8733Inferred only
GPAA1 participates in Attachment of GPI anchor to uPARPathwayReactome R-HSA-162791Inferred only
GPAA1 participates in Glycosylphosphatidyl inositol anchor pathwayPathwayWikiPathways WP5505Inferred only
GPAA1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
GPAA1 participates in Post-translational modification: synthesis of GPI-anchored proteinsPathwayReactome R-HSA-163125Inferred only

Show the remaining 15

GPAA1 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ALMS1 increases the expression of GPAA1ProteinHetionet hetionet:regulates:7840-8733Inferred only
AP2A2 decreases the expression of GPAA1ProteinHetionet hetionet:regulates:161-8733Inferred only
ATF6 decreases the expression of GPAA1ProteinHetionet hetionet:regulates:22926-8733Inferred only
AXIN2 decreases the expression of GPAA1ProteinHetionet hetionet:regulates:8313-8733Inferred only
ENTPD6 decreases the expression of GPAA1ProteinHetionet hetionet:regulates:955-8733Inferred only
GMDS decreases the expression of GPAA1ProteinHetionet hetionet:regulates:2762-8733Inferred only
MCM2 decreases the expression of GPAA1ProteinHetionet hetionet:regulates:4171-8733Inferred only
MECP2 decreases the expression of GPAA1ProteinHetionet hetionet:regulates:4204-8733Inferred only
NT5E decreases the expression of GPAA1ProteinHetionet hetionet:regulates:4907-8733Inferred only
NXF1 decreases the expression of GPAA1ProteinHetionet hetionet:regulates:10482-8733Inferred only
PANK4 decreases the expression of GPAA1ProteinHetionet hetionet:regulates:55229-8733Inferred only
PUF60 decreases the expression of GPAA1ProteinHetionet hetionet:regulates:22827-8733Inferred only
TBXA2R decreases the expression of GPAA1ProteinHetionet hetionet:regulates:6915-8733Inferred only
TP53 decreases the expression of GPAA1ProteinHetionet hetionet:regulates:7157-8733Inferred only

Reactions

5 reactions

MAM02001r+MAM03749rMAM02022r+MAM03750r
Catalysed by GPAA1 & PIGK & PIGS & PIGU
Reaction pageLeft to rightBalance undeterminableEC 1.4.3.14endoplasmic reticulum
Human-GEM MAR01511CC BY 4.0Reference data
MAM01779r+MAM02001rMAM01780r+MAM02022r
Catalysed by GPAA1 & PIGK & PIGT & PIGS & PIGU

Other names

5 names

Resolves to: GPAA1

Also called: GAA1GAA1 protein homologGlycosylphosphatidylinositol anchor attachment 1 proteinGPI anchor attachment protein 1hGAA1

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