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Proteins/UNIPROT:Q8WZ64

ARAP2

Protein·UNIPROT:Q8WZ64

Open in the graph

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity)..

Function from UniProtKB (Q8WZ64), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

13 statements

13 statements · 3 reference databases · Subject: ARAP2 · Sources: gene ontology, Hetionet, Reactome

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ARAP2 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
ARAP2 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
ARAP2 participates in RAC3 GTPase cyclePathwayReactome R-HSA-9013423Inferred only
ARAP2 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
ARAP2 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
ARAP2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ARAP2 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
ARAP2 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ARAP2 regulates regulation of actin cytoskeleton organizationBiological processgene ontology Q8WZ64|GO:0032956Inferred only
ENTPD6 increases the expression of ARAP2ProteinHetionet hetionet:regulates:955-116984Inferred only
NDUFA5 increases the expression of ARAP2ProteinHetionet hetionet:regulates:4698-116984Inferred only
OVOL2 increases the expression of ARAP2ProteinHetionet hetionet:regulates:58495-116984Inferred only

Show the remaining 1

TPD52L2 increases the expression of ARAP2ProteinHetionet hetionet:regulates:7165-116984Inferred only

Other names

6 names

Resolves to: ARAP2

Also called: Centaurin-delta-1CENTD1Cnt-d1KIAA0580PARXProtein PARX

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