Proteins/UNIPROT:P62068

USP46

ProteinUNIPROT:P62068

Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2..

Function from UniProtKB (P62068), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

22 statements

22 statements · 2 reference databases · Subject: USP46 · Sources: gene ontology, Hetionet

Order

USP46 covaries with APBB2ProteinHetionet hetionet:covaries:323-64854Inferred only
USP46 covaries with GRIN2DProteinHetionet hetionet:covaries:2906-64854Inferred only
USP46 covaries with PCBP1ProteinHetionet hetionet:covaries:5093-64854Inferred only
USP46 covaries with SART1ProteinHetionet hetionet:covaries:64854-9092Inferred only
H2AC20 interacts with USP46ProteinHetionet hetionet:interacts:64854-8338Inferred only
H2BC21 interacts with USP46ProteinHetionet hetionet:interacts:64854-8349Inferred only
PHLPP1 interacts with USP46ProteinHetionet hetionet:interacts:23239-64854Inferred only
UBC interacts with USP46ProteinHetionet hetionet:interacts:64854-7316Inferred only
USP46 interacts with WDR20ProteinHetionet hetionet:interacts:64854-91833Inferred only
USP46 regulates positive regulation of canonical Wnt signaling pathwayBiological processgene ontology P62068|GO:0090263Inferred only
USP46 regulates regulation of postsynaptic neurotransmitter receptor internalizationBiological processgene ontology P62068|GO:0099149Inferred only
USP46 regulates regulation of synaptic transmission, GABAergicBiological processgene ontology P62068|GO:0032228Inferred only

Show the remaining 10

CREB3L2 increases the expression of USP46ProteinHetionet hetionet:regulates:64764-64854Inferred only
DHX29 increases the expression of USP46ProteinHetionet hetionet:regulates:54505-64854Inferred only
EGR1 decreases the expression of USP46ProteinHetionet hetionet:regulates:1958-64854Inferred only
ENTPD6 increases the expression of USP46ProteinHetionet hetionet:regulates:955-64854Inferred only
GMDS increases the expression of USP46ProteinHetionet hetionet:regulates:2762-64854Inferred only
HMGB1 increases the expression of USP46ProteinHetionet hetionet:regulates:3146-64854Inferred only
PAFAH1B3 increases the expression of USP46ProteinHetionet hetionet:regulates:5050-64854Inferred only
RAD9A increases the expression of USP46ProteinHetionet hetionet:regulates:5883-64854Inferred only
RPS27A increases the expression of USP46ProteinHetionet hetionet:regulates:6233-64854Inferred only
SGCB decreases the expression of USP46ProteinHetionet hetionet:regulates:6443-64854Inferred only

Reactions

1 reaction

water+MAM03104cproton+a thiol+MAM03105c
Catalysed by USP2 or USP28 or USP36 or USP13 or OTUD5 or USP33 or CYLD or USP40 or USP48 or USP14 or USP10 or USP31 and 43 more alternatives
Reaction pageLeft to rightBalance undeterminable

Other names

3 names

Resolves to: USP46

Also called: Deubiquitinating enzyme 46Ubiquitin thioesterase 46Ubiquitin-specific-processing protease 46

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