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Proteins/UNIPROT:Q9Y227
[Isoform 1]: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates. Preferentially activated by Ca(2+) over Mg(2+)..
[Isoform 2]: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally..
Function from UniProtKB (Q9Y227), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
52 statements
52 statements · 7 reference databases · Subject: ENTPD4 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt
15 reactions
water+UDPproton+phosphate(3-)+UMP
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6endoplasmic reticulum
Human-GEM MAR04059CC BY 4.0Reference data
8 names
Resolves to: ENTPD4
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6extracellular space
Human-GEM MAR04060CC BY 4.0Reference data
GDP+waterGMP+proton+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6, 3.6.1.42extracellular space
Human-GEM MAR04134CC BY 4.0Reference data
GTP+waterGDP+proton+phosphate(3-)
Catalysed by ENTPD2 or DNM2 or DNM1L or DNM1 or ENTPD1 or EFL1 or EEF1A1 or GFM2 or EEF2 or ENTPD3 or GFM1 or CANT1 and 5 more alternatives
Reaction pageLeft to rightBalancedEC 3.6.5.1, 3.6.5.2, 3.6.5.3, 3.6.5.4, 3.6.5.5, 3.6.5.6extracellular space
Human-GEM MAR04136CC BY 4.0Reference data
water+CHEBI:17808proton+CHEBI:17202+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6extracellular space
Human-GEM MAR04342CC BY 4.0Reference data
ATP+2waterAMP+2proton+2phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6, 3.6.1.42extracellular space
Human-GEM MAR08474CC BY 4.0Reference data
water+UDPproton+phosphate(3-)+UMP
Catalysed by CANT1 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.6Golgi apparatus
Human-GEM MAR08485CC BY 4.0Reference data
GTP+waterGDP+hydrogenphosphate+hydron
Catalysed by IRGM or RAB19 or TUBAL3 or GTPBP1 or RAB27B or RHOD or DNM1L or MRAS or RAB29 or OPA1 or EIF5B or ENTPD3 and 183 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:19669CC BY 4.0Reference data
GDP+waterGMP+hydrogenphosphate+hydron
Catalysed by ENTPD6 or ENTPD3 or ENTPD5 or GBP1 or ENTPD1 or GBP7 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:22156CC BY 4.0Reference data
a ribonucleoside 5'-triphosphate+watera ribonucleoside 5'-diphosphate+hydrogenphosphate+hydron
Catalysed by ENTPD3 or ENTPD1 or ENTPD8 or SMPDL3A or NTPCR or ENTPD7 or DDX20 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:23680CC BY 4.0Reference data
CTP+waterCDP+hydrogenphosphate+hydron
Catalysed by ENTPD3 or ENTPD1 or ABCE1 or NTPCR or ENTPD7 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:29387CC BY 4.0Reference data
a ribonucleoside 5'-diphosphate+waterCHEBI:58043+hydrogenphosphate+hydron
Catalysed by ENTPD6 or ENTPD3 or ENTPD5 or ENTPD1 or ENTPD8 or CANT1 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36799CC BY 4.0Reference data