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Proteins/UNIPROT:Q9Y617
Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. Acts as an inhibitor of ferroptosis in response to interferon-gamma (IFNG) by promoting GPX4 stability: following phosphorylation by CAMK2A, PSAT1 interacts with GPX4 and provides 2-oxoglutarate to EGLN3, leading to GPX4 hydroxylation and stability..
Function from UniProtKB (Q9Y617), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
63 statements
63 statements · 5 reference databases · Subject: PSAT1 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
2 reactions
MAM00914c+L-glutamate(1-)MAM00916c+2-oxoglutarate(2-)
Catalysed by PSAT1
Reaction pageReversibleBalancedEC 2.6.1.52cytosol
Human-GEM MAR03841CC BY 4.0Reference data
CHEBI:57524+2-oxoglutarate(2-)CHEBI:18110+L-glutamate(1-)
Catalysed by PSAT1
Reaction pageRight to leftBalanced
Rhea RHEA:14329CC BY 4.0Reference data
3 names
Resolves to: PSAT1