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Proteins/UNIPROT:Q7Z2Z2
GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export..
Function from UniProtKB (Q7Z2Z2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
14 statements
14 statements · 2 reference databases · Subject: EFL1 · Sources: Hetionet, WikiPathways
2 reactions
5 names
Resolves to: EFL1
Human-GEM MAR04136CC BY 4.0Reference data
GTP+waterGDP+hydrogenphosphate+hydron
Catalysed by IRGM or RAB19 or TUBAL3 or GTPBP1 or RAB27B or RHOD or DNM1L or MRAS or RAB29 or OPA1 or EIF5B or ENTPD3 and 183 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:19669CC BY 4.0Reference data