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Proteins/UNIPROT:O75356
Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP. In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity)..
Function from UniProtKB (O75356), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
38 statements
38 statements · 7 reference databases · Subject: ENTPD5 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt
13 reactions
ADP+waterAMP+proton+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6cytosol
Human-GEM MAR03998CC BY 4.0Reference data
12 names
Resolves to: ENTPD5
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6endoplasmic reticulum
Human-GEM MAR04059CC BY 4.0Reference data
water+UDPproton+phosphate(3-)+UMP
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6extracellular space
Human-GEM MAR04060CC BY 4.0Reference data
GDP+waterGMP+proton+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6, 3.6.1.42extracellular space
Human-GEM MAR04134CC BY 4.0Reference data
GTP+waterGDP+proton+phosphate(3-)
Catalysed by ENTPD2 or DNM2 or DNM1L or DNM1 or ENTPD1 or EFL1 or EEF1A1 or GFM2 or EEF2 or ENTPD3 or GFM1 or CANT1 and 5 more alternatives
Reaction pageLeft to rightBalancedEC 3.6.5.1, 3.6.5.2, 3.6.5.3, 3.6.5.4, 3.6.5.5, 3.6.5.6extracellular space
Human-GEM MAR04136CC BY 4.0Reference data
water+CHEBI:17808proton+CHEBI:17202+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6extracellular space
Human-GEM MAR04342CC BY 4.0Reference data
ATP+2waterAMP+2proton+2phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6, 3.6.1.42extracellular space
Human-GEM MAR08474CC BY 4.0Reference data
GDP+waterGMP+hydrogenphosphate+hydron
Catalysed by ENTPD6 or ENTPD3 or ENTPD5 or GBP1 or ENTPD1 or GBP7 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:22156CC BY 4.0Reference data
IDP+waterIMP+hydrogenphosphate+hydron
Catalysed by ENTPD6 or ENTPD3 or ENTPD5 or ENTPD1 or NUDT16 or ENTPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:35207CC BY 4.0Reference data
a ribonucleoside 5'-diphosphate+waterCHEBI:58043+hydrogenphosphate+hydron
Catalysed by ENTPD6 or ENTPD3 or ENTPD5 or ENTPD1 or ENTPD8 or CANT1 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36799CC BY 4.0Reference data
ADP(3-)+waterAMP+hydrogenphosphate+hydron
Catalysed by ENTPD3 or ENTPD5 or ALPL or ENTPD1 or ADPRM or ENTPD8 or ENTPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:61436CC BY 4.0Reference data
UDP+waterUMP+hydrogenphosphate+hydron
Catalysed by ENTPD6 or ENTPD3 or ENTPD5 or ENTPD1 or ENTPD8 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalanced
Rhea RHEA:64876CC BY 4.0Reference data