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Proteins/UNIPROT:P13637
Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze against their electrochemical gradients to maintain ion concentration gradients across the membranes (By similarity). In the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation..
Function from UniProtKB (P13637), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
7 rows
130 statements
130 statements · 9 reference databases · Subject: ATP1A3 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
ATP+water+2potassium atom+3sodium(1+)ADP+proton+2potassium atom+3sodium(1+)+phosphate(3-)
Transported by ATP1A1 & FXYD2 & ATP1B4 or ATP1B2 & ATP1A2 & FXYD2 or ATP1A2 & ATP1B3 &
3 names
Resolves to: ATP1A3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05429CC BY 4.0Reference data
2K(+)+3sodium(1+)+ATP(4-)+water2K(+)+3sodium(1+)+ADP(3-)+hydrogenphosphate+hydron
Transported by ATP1A1 or ATP1A3 or ATP1A2 or ATP12A or ATP1A4
Reaction pageLeft to rightBalanced
Rhea RHEA:18353CC BY 4.0Reference data