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Proteins/UNIPROT:P48023
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis..
[Tumor necrosis factor ligand superfamily member 6, soluble form]: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process..
[FasL intracellular domain]: Cytoplasmic form induces gene transcription inhibition..
Function from UniProtKB (P48023), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
226 statements
226 statements · 4 reference databases · Subject: FASLG · Sources: gene ontology, Hetionet, Reactome, WikiPathways
19 names
Resolves to: FASLG