H1-4

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Ability to associate with nucleosomes and compact chromatin depends on linker DNA length and trajectory. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation..

Function from UniProtKB (P10412), read 2026-09-23. CC BY 4.0.