Compound

(2E,6E)-farnesyl diphosphate

An organophosphate oxoanion that is the trianion obtained by removal of the three protons from the diphosphate group of 2-trans,6-trans-farnesyl diphosphate.

Definition from ChEBI (CHEBI:175763), read 2026-09-23. CC BY 4.0.

CHEBI:175763ChEBI

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Structure

2D depiction · 3D model shown

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A generated conformer of (2E,6E)-farnesyl diphosphate — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C15H25O7P2
Mass: 379.306 g/mol
Charge: -3
InChIKey: VWFJDQUYCIWHTN-YFVJMOTDSA-K
SMILES: CC(C)=CCC/C(C)=C/CC/C(C)=C/COP(=O)([O-])OP(=O)([O-])[O-]
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

14 entities

14 entities reached.

0 reported hops14 assembled from the scaffold

Show the remaining 2

What the reference databases state

Statements

45 statements

45 statements · 2 reference databases · Subject: (2E,6E)-farnesyl diphosphate · Sources: Human-GEM, Rhea

Order

(2E,6E)-farnesyl diphosphate is converted to (2E,6E)-farnesolCompoundRhea RHEA:27526Inferred only
(2E,6E)-farnesol is converted to (2E,6E)-farnesyl diphosphateCompoundRhea RHEA:27526Inferred only
(2E,6E)-farnesyl phosphate is converted to (2E,6E)-farnesyl diphosphateCompoundRhea RHEA:51684Inferred only
(2E,6E)-farnesyl diphosphate is converted to (2E,6E)-farnesyl phosphateCompoundRhea RHEA:48128Inferred only
(2E,6E)-farnesyl diphosphate is converted to (2E,6E)-farnesyl phosphateCompoundRhea RHEA:51684Inferred only
(2E,6E)-farnesyl diphosphate is converted to (2E,6E)-farnesyl triphosphateCompoundRhea RHEA:21544Inferred only
(2E,6E)-farnesyl diphosphate is converted to presqualene diphosphateCompoundHuman-GEM MAR02026Inferred only
(2E,6E)-farnesyl diphosphate is converted to presqualene diphosphateCompoundHuman-GEM MAR01465Inferred only
(2E,6E)-farnesyl diphosphate is converted to presqualene diphosphateCompoundRhea RHEA:22672Inferred only
(2E,6E)-farnesyl diphosphate is converted to squaleneCompoundRhea RHEA:32295Inferred only
(2E,6E)-farnesyl diphosphate is converted to squaleneCompoundHuman-GEM MAR01715Inferred only
(2E,6E)-farnesyl diphosphate is converted to squaleneCompoundRhea RHEA:32299Inferred only

Show the remaining 33

(2E,6E)-farnesyl diphosphate is a substrate of COX10ProteinHuman-GEM MAR20091Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of COX10ProteinHuman-GEM MAR20090Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of COX10ProteinRhea RHEA:28070Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of COX10ProteinHuman-GEM MAR20092Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of DHDDSProteinRhea RHEA:53008Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of DHDDSProteinHuman-GEM MAR20098Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of FDFT1ProteinHuman-GEM MAR02026Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of FDFT1ProteinRhea RHEA:32295Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of FDFT1ProteinHuman-GEM MAR01715Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of FDFT1ProteinRhea RHEA:22672Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of FDFT1ProteinHuman-GEM MAR01465Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of FDFT1ProteinRhea RHEA:32299Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of FDPSProteinRhea RHEA:19361Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of FDPSProteinHuman-GEM MAR01532Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of FNTAProteinHuman-GEM MAR07166Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of FNTAProteinRhea RHEA:13345Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of FNTBProteinRhea RHEA:13345Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of FNTBProteinHuman-GEM MAR07166Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of GGPS1ProteinHuman-GEM MAR01532Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of GGPS1ProteinRhea RHEA:17653Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of GGPS1ProteinRhea RHEA:19361Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of GGPS1ProteinHuman-GEM MAR11408Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of NME1ProteinRhea RHEA:21544Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of NUDT15ProteinRhea RHEA:48128Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of NUDT18ProteinRhea RHEA:48128Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of NUS1ProteinRhea RHEA:53008Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of PDSS1ProteinHuman-GEM MAR06901Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of PDSS1ProteinRhea RHEA:27802Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of PDSS1ProteinRhea RHEA:55364Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of PDSS2ProteinRhea RHEA:55364Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of PDSS2ProteinHuman-GEM MAR06901Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of PDSS2ProteinRhea RHEA:27802Inferred only
(2E,6E)-farnesyl diphosphate is a substrate of PLPP6ProteinRhea RHEA:48128Inferred only

Reactions

207 reactions

(2E,6E)-farnesyl diphosphate(2E,6E)-farnesyl diphosphate
Reaction pageReversibleBalancedEC 6.3.2.17peroxisome, cytosol
Human-GEM MAR01051CC BY 4.0Reference data
(2E,6E)-farnesyl diphosphate(2E,6E)-farnesyl diphosphate
Reaction pageReversibleBalancedEC 6.3.2.17peroxisome, endoplasmic reticulum
Human-GEM MAR01052CC BY 4.0Reference data
(2E)-geranyl diphosphate+isopentenyl diphosphate(2E,6E)-farnesyl diphosphate+diphosphate(3-)
Catalysed by FDPS
Reaction pageLeft to rightBalancedEC 2.5.1.10peroxisome
Human-GEM MAR01397CC BY 4.0Reference data
(2E)-geranyl diphosphate+isopentenyl diphosphate(2E,6E)-farnesyl diphosphate+diphosphate(3-)
Catalysed by GGPS1 or FDPS
Reaction pageLeft to rightBalancedEC 2.5.1.1, 2.5.1.10, 2.5.1.29cytosol
Human-GEM MAR01460CC BY 4.0Reference data
2(2E,6E)-farnesyl diphosphatediphosphate(3-)+presqualene diphosphate
Catalysed by FDFT1
Reaction pageLeft to rightBalancedEC 2.5.1.21cytosol
Human-GEM MAR01465CC BY 4.0Reference data
MAM01706c+(2E,6E)-farnesyl diphosphatediphosphate(3-)+MAM03026c
Catalysed by GGPS1 or FDPS
Reaction pageLeft to rightBalancedEC 2.5.1.10cytosol
Human-GEM MAR01532CC BY 4.0Reference data
2(2E,6E)-farnesyl diphosphate+proton+NADPH(4-)NADP(3-)+2diphosphate(3-)+squalene
Catalysed by FDFT1
Reaction pageLeft to rightBalancedEC 2.5.1.21endoplasmic reticulum
Human-GEM MAR01715CC BY 4.0Reference data
2(2E,6E)-farnesyl diphosphatediphosphate(3-)+presqualene diphosphate
Catalysed by FDFT1
Reaction pageLeft to rightBalancedEC 2.5.1.21endoplasmic reticulum
Human-GEM MAR02026CC BY 4.0Reference data
(2E,6E)-farnesyl diphosphate+7isopentenyl diphosphateall-trans-decaprenyl diphosphate+7diphosphate(3-)
Catalysed by PDSS1 or PDSS2
Reaction pageLeft to rightBalancedEC 2.5.1.91cytosol
Human-GEM MAR06901CC BY 4.0Reference data
MAM00200c+(2E,6E)-farnesyl diphosphatediphosphate(3-)+MAM02898c
Catalysed by FNTA & FNTB
Reaction pageLeft to rightBalance undeterminableEC 2.5.1.58cytosol
Human-GEM MAR07166CC BY 4.0Reference data
(2E,6E)-farnesyl diphosphate(2E,6E)-farnesyl diphosphate
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR08970CC BY 4.0Reference data
(2E,6E)-farnesyl diphosphate+isopentenyl diphosphatediphosphate(3-)+(2E,6E,10E)-geranylgeranyl diphosphate
Catalysed by GGPS1
Reaction pageLeft to rightBalancedEC 2.5.1.29cytosol
Human-GEM MAR11408CC BY 4.0Reference data

Show the remaining 195

Other names

12 names

Resolves to: (2E,6E)-farnesyl diphosphate

Also called: (2-trans,6-trans)-farnesyl diphosphate(3-)(2-trans,6-trans)-farnesyl diphosphate(3−)(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl (phosphonatooxy)phosphonate(2E,6E)-farnesyl diphosphate(3-)(2E,6E)-farnesyl diphosphate(3−)(E,E)-farnesyl diphosphate(3-)(E,E)-farnesyl diphosphate(3−)farnesyl pyrophosphate(3-)farnesyl pyrophosphate(3−)trans,trans-farnesyl diphosphate(3-)trans,trans-farnesyl diphosphate(3−)
Systematic name: (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl diphosphate