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Proteins/UNIPROT:Q96E22
With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator..
Function from UniProtKB (Q96E22), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
25 statements
25 statements · 5 reference databases · Subject: NUS1 · Sources: gene ontology, Human Protein Atlas, Reactome, Rhea, UniProt
1 reaction
nisopentenyl diphosphate+(2E,6E)-farnesyl diphosphatea di-trans,poly-cis-polyprenyl diphosphate+ndiphosphate(3-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:53008CC BY 4.0Reference data
5 names
Resolves to: NUS1