FOXM1

[Isoform 5]: Required for the activation of Rho-associated protein kinases ROCK1 and ROCK2 and promotes epithelial-mesenchymal transition. Enhances the activation of phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) by binding simultaneously to the catalytic and regulatory subunits. This relieves the inhibitory effect of the regulatory subunit on the kinase activity of the catalytic subunit, resulting in downstream signaling events such as AKT activation, GSK3B inactivation, and increased levels of SNAI1. Promotes glycolysis by binding to the pyruvate kinase PKM homotetramer to form a heterooctamer, inhibiting PKM activity. Promotes the IMP4-mediated nuclear translocation of both PKM and the NF-kappa-B complex which increases transcription of VEGFA, leading to increased angiogenesis..