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Proteins/UNIPROT:P49914
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate..
Function from UniProtKB (P49914), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
19 statements
19 statements · 5 reference databases · Subject: MTHFS · Sources: Hetionet, Reactome, Rhea, UniProt, WikiPathways
3 reactions
MAM01100m+ATP(6R)-5,10-methenyltetrahydrofolate+ADP+phosphate(3-)
Catalysed by MTHFS
Reaction pageLeft to rightBalancedEC 6.3.3.2mitochondrial matrix
Human-GEM MAR04666CC BY 4.0Reference data
MAM01100c+ATP(6R)-5,10-methenyltetrahydrofolate+ADP+phosphate(3-)
Catalysed by MTHFS
2 names
Resolves to: MTHFS
Human-GEM MAR08143CC BY 4.0Reference data
CHEBI:57457+ATP(4-)(6R)-5,10-methenyltetrahydrofolate+ADP(3-)+hydrogenphosphate
Catalysed by MTHFS
Reaction pageDirection not assertedBalanced
Rhea RHEA:10488CC BY 4.0Reference data