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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q9BXJ7

AMN

Protein·UNIPROT:Q9BXJ7

Open in the graph

Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface. The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12. Required for normal CUBN-mediated protein transport in the kidney (Probable)..

Function from UniProtKB (Q9BXJ7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

Imerslund-Grasbeck syndrome has a germline basis in AMNDiseaseGenCC HGNC:14604|MONDO:0009853Inferred only
Imerslund-Grasbeck syndrome type 1 has a germline basis in AMNDiseaseGenCC HGNC:14604|MONDO:0100156Inferred only
Imerslund-Grasbeck syndrome type 2 has a germline basis in AMNDiseaseGenCC HGNC:14604|MONDO:0100157Inferred only

Statements

16 statements

16 statements · 2 reference databases · Subject: AMN · Sources: Hetionet, Reactome

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STAMBP interacts with AMNProteinHetionet hetionet:interacts:10617-81693Inferred only
AMN participates in Cobalamin (Cbl, vitamin B12) transport and metabolismPathwayReactome R-HSA-196741Inferred only
AMN participates in Defective AMN causes MGA1PathwayReactome R-HSA-3359462Inferred only
AMN participates in Defective CUBN causes MGA1PathwayReactome R-HSA-3359463Inferred only
AMN participates in Defects in cobalamin (B12) metabolismPathwayReactome R-HSA-3296469Inferred only
AMN participates in Defects in vitamin and cofactor metabolismPathwayReactome R-HSA-3296482Inferred only
AMN participates in DiseasePathwayReactome R-HSA-1643685Inferred only
AMN participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
AMN participates in HDL clearancePathwayReactome R-HSA-8964011Inferred only
AMN participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
AMN participates in Metabolism of vitamins and cofactorsPathwayReactome R-HSA-196854Inferred only
AMN participates in Metabolism of water-soluble vitamins and cofactorsPathwayReactome R-HSA-196849Inferred only

Show the remaining 4

AMN participates in Plasma lipoprotein assembly, remodeling, and clearancePathwayReactome R-HSA-174824Inferred only
AMN participates in Plasma lipoprotein clearancePathwayReactome R-HSA-8964043Inferred only
AMN participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
AMN participates in Uptake of dietary cobalamins into enterocytesPathwayReactome R-HSA-9758881Inferred only

Reactions

1 reaction

MAM01600eMAM01600c
Transported by CUBN & CBLIF & AMN
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06884CC BY 4.0Reference data

Other names

2 names

Resolves to: AMN

Also called: amnionless [Cleaved into: Soluble protein amnionless]Protein amnionless [Cleaved into: Soluble protein amnionless]

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