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Proteins/UNIPROT:P14207
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release..
Function from UniProtKB (P14207), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
27 statements
27 statements · 5 reference databases · Subject: FOLR2 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways
2 reactions
Transported by FOLR1 or FOLR3 or FOLR2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05007CC BY 4.0Reference data
(6R)-5,10-methylenetetrahydrofolic acid(6R)-5,10-methylenetetrahydrofolic acid
Transported by FOLR1 or FOLR3 or FOLR2
Reaction pageLeft to rightBalancedEC 7.6.2.2extracellular space, cytosol
5 names
Resolves to: FOLR2