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Proteins/UNIPROT:Q8N695
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline). Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced. Part of D-serine transport systems. May contribute to D-serine reabsorption at the brush border of renal proximal tubules thus modulating the dynamics of urinary versus blood D-serine levels..
Function from UniProtKB (Q8N695), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
50 statements
50 statements · 5 reference databases · Subject: SLC5A8 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
21 reactions
Transported by SLC5A8
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07739CC BY 4.0Reference data
(S)-lactic acid+sodium(1+)(S)-lactic acid+sodium(1+)
Transported by SLC5A8
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR08515CC BY 4.0Reference data
7 names
Resolves to: SLC5A8
Transported by SLC5A8
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09874CC BY 4.0Reference data
sodium(1+)+nicotinic acidsodium(1+)+nicotinic acid
Transported by SLC5A8
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09896CC BY 4.0Reference data
sodium(1+)+propionic acidsodium(1+)+propionic acid
Transported by SLC5A8
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09900CC BY 4.0Reference data
sodium(1+)+pyruvatesodium(1+)+pyruvate
Transported by SLC5A8
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09902CC BY 4.0Reference data
Transported by GABRR3 or GPHRA or KCNK1 or CLIC1 or GABRP or CLDN4 or GABRD or CLIC2 or SLC26A4 or GLRA3 or BEST1 or KCNK2 and 69 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29823CC BY 4.0Reference data
Transported by CLIC1 or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN17 or CLDN10 or AQP6 or SLC1A5 or SLC5A8 or SLC26A7 and 3 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:34923CC BY 4.0Reference data
Transported by GPHRA or CLIC1 or CLDN4 or SLC26A4 or GPHRB or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 and 14 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:66324CC BY 4.0Reference data
D-serine+2sodium(1+)D-serine+2sodium(1+)
Transported by SLC5A8
Reaction pageDirection not assertedBalanced
Rhea RHEA:68260CC BY 4.0Reference data
(S)-lactate+2sodium(1+)(S)-lactate+2sodium(1+)
Transported by SLC5A8
Reaction pageDirection not assertedBalanced
Rhea RHEA:72935CC BY 4.0Reference data
propanoate+2sodium(1+)propanoate+2sodium(1+)
Transported by SLC5A8
Reaction pageDirection not assertedBalanced
Rhea RHEA:72939CC BY 4.0Reference data