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Proteins/UNIPROT:Q9BQG2
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress. Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity)..
Function from UniProtKB (Q9BQG2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
50 statements
50 statements · 5 reference databases · Subject: NUDT12 · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, UniProt
6 reactions
deamido-NAD(+)+waterAMP+2proton+nicotinic acid D-ribonucleotide
Catalysed by NUDT12 or ENPP3 or ENPP1
Reaction pageLeft to rightBalancedEC 3.6.1.22, 3.6.1.9cytosol
Human-GEM MAR04255CC BY 4.0Reference data
4 names
Resolves to: NUDT12
Catalysed by NUDT12
Reaction pageLeft to rightBalancedEC 3.6.1.22cytosol
Human-GEM MAR04263CC BY 4.0Reference data
NAD(1-)+waterNMN zwitterion+AMP+2hydron
Catalysed by NUDT13 or NUDT12 or ENPP5
Reaction pageLeft to rightBalanced
Rhea RHEA:11800CC BY 4.0Reference data
NADH(2-)+waterreduced beta-nicotinamide D-ribonucleotide+AMP+2hydron
Catalysed by NUDT6 or NUDT13 or FLAD1 or NUDT12
Reaction pageLeft to rightBalanced
Rhea RHEA:48868CC BY 4.0Reference data
NADPH(4-)+waterreduced beta-nicotinamide D-ribonucleotide+adenosine 2',5'-bisphosphate+2hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:60820CC BY 4.0Reference data
a 5'-end NAD(+)-phospho-ribonucleoside in mRNA+watera 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA+NMN zwitterion+2hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60876CC BY 4.0Reference data