Loading the page.
Proteins/UNIPROT:Q9BZ23
[Isoform 1]: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC)..
[Isoform 4]: Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis..
Function from UniProtKB (Q9BZ23), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
42 statements
42 statements · 7 reference databases · Subject: PANK2 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
ATP+pantothenic acidADP+(R)-4'-phosphopantothenate+proton
Catalysed by PANK2
Reaction pageLeft to rightBalancedEC 2.7.1.33mitochondrial matrix
Human-GEM MAR01634CC BY 4.0Reference data
ATP+(R)-pantetheineADP+proton+pantetheine 4'-phosphate
Catalysed by PANK3 or
6 names
Resolves to: PANK2
Reaction pageLeft to rightBalancedEC 2.7.1.33, 2.7.1.34cytosol
Human-GEM MAR04714CC BY 4.0Reference data
ATP+(R)-pantetheineADP+proton+pantetheine 4'-phosphate
Catalysed by PANK3 or PANK2 or PANK1
Reaction pageLeft to rightBalancedEC 2.7.1.33, 2.7.1.34mitochondrial matrix
Human-GEM MAR04715CC BY 4.0Reference data
ATP+pantothenic acidADP+(R)-4'-phosphopantothenate+proton
Catalysed by PANK3 or PANK2 or PANK1
Reaction pageLeft to rightBalancedEC 2.7.1.33cytosol
Human-GEM MAR04718CC BY 4.0Reference data
N-[(R)-4-phosphopantothenoyl]-L-cysteine+ADP+protonATP+MAM02623c
Catalysed by PANK3 or PANK2 or PANK1
Reaction pageReversibleBalancedEC 2.7.1.33cytosol
Human-GEM MAR04730CC BY 4.0Reference data
N-[(R)-4-phosphopantothenoyl]-L-cysteine+ADP+protonATP+MAM02623m
Catalysed by PANK2
Reaction pageReversibleBalancedEC 2.7.1.33mitochondrial matrix
Human-GEM MAR04731CC BY 4.0Reference data
(R)-pantothenate+ATP(4-)(R)-4'-phosphopantothenate+ADP(3-)+hydron
Catalysed by PANK1 or PANK2 or PANK3
Reaction pageDirection not assertedBalanced
Rhea RHEA:16373CC BY 4.0Reference data