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Proteins/UNIPROT:Q10588
Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable)..
Function from UniProtKB (Q10588), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
30 statements
30 statements · 6 reference databases · Subject: BST1 · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea, WikiPathways
6 reactions
water+NAD(+)ADP-D-ribose+proton+nicotinamide
Reaction pageLeft to rightBalancedEC 3.2.2.5extracellular space
Human-GEM MAR07142CC BY 4.0Reference data
water+NAD(+)ADP-D-ribose+proton+nicotinamide
Catalysed by CD38
6 names
Resolves to: BST1
Reaction pageLeft to rightBalancedEC 3.2.2.5cytosol
Human-GEM MAR07143CC BY 4.0Reference data
water+NADP(3-)CHEBI:37463+proton+nicotinamide
Reaction pageLeft to rightBalancedEC 3.2.2.5cytosol
Human-GEM MAR07627CC BY 4.0Reference data
NAD(1-)+waterADP-D-ribose+nicotinamide+hydron
Catalysed by IL18RAP or IL1R1 or CD38 or IL1RL1 or BST1 or IL18R1 or SARM1 or IL1RL2 or IL1RAPL2 or IL1RAP or IL1RAPL1
Reaction pageLeft to rightBalanced
Rhea RHEA:16301CC BY 4.0Reference data
NAD(1-)cyclic ADP-beta-D-ribose+nicotinamide+hydron
Catalysed by CD38 or BST1 or SARM1
Reaction pageLeft to rightBalanced
Rhea RHEA:38611CC BY 4.0Reference data
cyclic ADP-beta-D-ribose+waterADP-D-ribose
Reaction pageLeft to rightBalanced
Rhea RHEA:38615CC BY 4.0Reference data