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Proteins/UNIPROT:Q6IA69
Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source..
Function from UniProtKB (Q6IA69), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
142 statements
142 statements · 6 reference databases · Subject: NADSYN1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
ATP+deamido-NAD(+)+L-glutamine+waterAMP+L-glutamate(1-)+proton+NAD(+)+diphosphate(3-)
Catalysed by NADSYN1
Reaction pageLeft to rightBalancedEC 6.3.5.1cytosol
Human-GEM MAR04260CC BY 4.0Reference data
3 names
Resolves to: NADSYN1
Catalysed by NADSYN1
Reaction pageLeft to rightBalancedEC 6.3.5.1cytosol
Human-GEM MAR04261CC BY 4.0Reference data
ATP+deamido-NAD(+)+ammoniumAMP+NAD(+)+diphosphate(3-)
Catalysed by NADSYN1
Reaction pageLeft to rightBalancedEC 6.3.5.1nucleus
Human-GEM MAR04278CC BY 4.0Reference data
deamido-NAD(+)+L-glutamine+ATP(4-)+waterL-glutamate(1-)+AMP+diphosphate(3-)+NAD(1-)+hydron
Catalysed by NADSYN1
Reaction pageLeft to rightBalanced
Rhea RHEA:24384CC BY 4.0Reference data