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Proteins/UNIPROT:Q9H3S4
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism. By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis. Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence..
Function from UniProtKB (Q9H3S4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
16 statements
16 statements · 6 reference databases · Subject: TPK1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
ATP+thiamineAMP+proton+thiamine(1+) diphosphate
Catalysed by TPK1
Reaction pageLeft to rightBalancedEC 2.7.6.2cytosol
Human-GEM MAR04204CC BY 4.0Reference data
ATP+thiamine(1+) diphosphateADP+thiamine triphosphate
Catalysed by TPK1
Reaction pageLeft to rightBalancedEC 2.7.6.2cytosol
4 names
Resolves to: TPK1
Human-GEM MAR04206CC BY 4.0Reference data
thiamine+UTPthiamine diphosphate+UMP+hydron
Catalysed by TPK1
Reaction pageLeft to rightBalanced
Rhea RHEA:79423CC BY 4.0Reference data