Loading the page.
Proteins/UNIPROT:P50747
Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase..
Function from UniProtKB (P50747), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
22 statements
22 statements · 5 reference databases · Subject: HLCS · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
ATP+biotin+protonMAM01402m+diphosphate(3-)
Catalysed by HLCS
Reaction pageLeft to rightBalancedEC 6.3.4.15mitochondrial matrix
Human-GEM MAR00086CC BY 4.0Reference data
MAM01356m+MAM01402mAMP+MAM01357m+proton
Catalysed by HLCS
Reaction pageLeft to rightBalance undeterminableEC 3.5.1.12mitochondrial matrix
4 names
Resolves to: HLCS
ATP+biotin+protonMAM01402c+diphosphate(3-)
Catalysed by HLCS
Reaction pageLeft to rightBalancedEC 6.3.4.9, 6.3.4.10, 6.3.4.11, 6.3.4.15cytosol
Human-GEM MAR07668CC BY 4.0Reference data
MAM01356c+MAM01402cAMP+MAM01357c+proton
Catalysed by HLCS
Reaction pageLeft to rightBalance undeterminableEC 6.3.4.9, 6.3.4.10, 6.3.4.11, 6.3.4.15cytosol
Human-GEM MAR07670CC BY 4.0Reference data
apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]+biotin+ATP(4-)holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]+AMP+diphosphate(3-)+hydron
Catalysed by HLCS
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11204CC BY 4.0Reference data
biotin+L-lysyl-[protein]+ATP(4-)N(6)-biotinyl-L-lysyl-[protein]+AMP+diphosphate(3-)+hydron
Catalysed by HLCS
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11756CC BY 4.0Reference data
apo-[methylmalonyl-CoA:pyruvate carboxytransferase]+biotin+ATP(4-)holo-[methylmalonyl-CoA:pyruvate carboxytransferase]+AMP+diphosphate(3-)+hydron
Catalysed by HLCS
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:23668CC BY 4.0Reference data
apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]+biotin+ATP(4-)holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]+AMP+diphosphate(3-)+hydron
Catalysed by HLCS
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:24376CC BY 4.0Reference data