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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P07477

PRSS1

Protein·UNIPROT:P07477

Open in the graph

Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates..

Function from UniProtKB (P07477), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

hereditary chronic pancreatitis has a germline basis in PRSS1DiseaseGenCC HGNC:9475|MONDO:0008185Inferred only
malignant pancreatic neoplasm has a germline basis in PRSS1DiseaseGenCC HGNC:9475|MONDO:0009831Inferred only

Statements

24 statements

24 statements · 3 reference databases · Subject: PRSS1 · Sources: Hetionet, Reactome, UniProt

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APP interacts with PRSS1ProteinHetionet hetionet:interacts:351-5644Inferred only
DEFA5 interacts with PRSS1ProteinHetionet hetionet:interacts:1670-5644Inferred only
GRB2 interacts with PRSS1ProteinHetionet hetionet:interacts:2885-5644Inferred only
PRSS1 interacts with PTPN4ProteinHetionet hetionet:interacts:5644-5775Inferred only
SERPINA1 interacts with PRSS1ProteinHetionet hetionet:interacts:5265-5644Inferred only
SERPINB13 interacts with PRSS1ProteinHetionet hetionet:interacts:5275-5644Inferred only
SERPINB8 interacts with PRSS1ProteinHetionet hetionet:interacts:5271-5644Inferred only
SERPINF2 interacts with PRSS1ProteinHetionet hetionet:interacts:5345-5644Inferred only
PRSS1 interacts with SPINK5ProteinHetionet hetionet:interacts:11005-5644Inferred only
PRSS1 interacts with TSTProteinHetionet hetionet:interacts:5644-7263Inferred only
PRSS1 interacts with UBCProteinHetionet hetionet:interacts:5644-7316Inferred only
PRSS1 participates in Activation of Matrix MetalloproteinasesPathwayReactome R-HSA-1592389Inferred only

Show the remaining 12

PRSS1 participates in Cobalamin (Cbl, vitamin B12) transport and metabolismPathwayReactome R-HSA-196741Inferred only
PRSS1 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
PRSS1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
PRSS1 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
PRSS1 participates in Developmental Cell Lineages of the Exocrine PancreasPathwayReactome R-HSA-9820448Inferred only
PRSS1 participates in Developmental Lineage of Pancreatic Acinar CellsPathwayReactome R-HSA-9925561Inferred only
PRSS1 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
PRSS1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
PRSS1 participates in Metabolism of vitamins and cofactorsPathwayReactome R-HSA-196854Inferred only
PRSS1 participates in Metabolism of water-soluble vitamins and cofactorsPathwayReactome R-HSA-196849Inferred only
PRSS1 participates in Uptake of dietary cobalamins into enterocytesPathwayReactome R-HSA-9758881Inferred only
PRSS1 requires the cofactor Ca(2+)CompoundUniProt P07477Inferred only

Other names

11 names

Resolves to: PRSS1

Also called: [Cleaved into: Alpha-trypsin chain 1; Alpha-trypsin chain 2]Anionic trypsin IAnionic trypsin-IBeta-trypsinCationic trypsinogenPretrypsinogen ITRP1TRY1TRYP1Trypsin ITrypsin-1

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