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Proteins/UNIPROT:Q9Y289
Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide. Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane. Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier..
Function from UniProtKB (Q9Y289), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 3 · transported by
3 compounds
3 compounds.
0 reported routes3 assembled routes
3 rows
150 statements
150 statements · 6 reference databases · Subject: SLC5A6 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
12 reactions
ATP+biotin+water+sodium(1+)ADP+biotin+proton+sodium(1+)+phosphate(3-)
Transported by SLC5A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00094CC BY 4.0Reference data
4 names
Resolves to: SLC5A6
Transported by SLC5A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01636CC BY 4.0Reference data
sodium(1+)+pantothenic acidsodium(1+)+pantothenic acid
Transported by SLC5A6
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04721CC BY 4.0Reference data
ATP+biotin+water+2sodium(1+)ADP+biotin+proton+2sodium(1+)+phosphate(3-)
Transported by SLC5A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07667CC BY 4.0Reference data
ATP+water+2sodium(1+)+pantothenic acidADP+proton+2sodium(1+)+pantothenic acid+phosphate(3-)
Transported by SLC5A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR08930CC BY 4.0Reference data
2sodium(1+)+pantothenic acid2sodium(1+)+pantothenic acid
Transported by SLC5A6
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09607CC BY 4.0Reference data
(R)-lipoate+2sodium(1+)(R)-lipoate+2sodium(1+)
Transported by SLC5A6
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09608CC BY 4.0Reference data
biotin+2sodium(1+)biotin+2sodium(1+)
Transported by SLC5A6
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09609CC BY 4.0Reference data
iodide+2sodium(1+)iodide+2sodium(1+)
Transported by SLC5A5 or SLC5A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:71207CC BY 4.0Reference data
(R)-pantothenate+2sodium(1+)(R)-pantothenate+2sodium(1+)
Transported by SLC5A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:73371CC BY 4.0Reference data
biotin+2sodium(1+)biotin+2sodium(1+)
Transported by SLC5A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:73375CC BY 4.0Reference data
(R)-lipoate+2sodium(1+)(R)-lipoate+2sodium(1+)
Transported by SLC5A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:73379CC BY 4.0Reference data