N-tetradecanoylglycine

Two steps

• L-glutamineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by GLYATL2, SLC7A5extracellular space, cytosolOne of 4 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by GLYATL2, GARTcytosol

• ophthalmateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by GLYATL2, GSS

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by GLYATL2, AGXT2

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by GLYATL2, SHMT1cytosolOne of 2 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. stearoyl-CoA 9-desaturase (myristoyl-CoA)

  Catalysed by GLYATL2, SCD, SCD5cytosol

• CHEBI:240943Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GLYATL2, GLYAT, GLYATL1mitochondrial matrix

• phenylacetylglycineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by GLYATL2, GLYATcytosolOne of 3 routes

• CHEBI:28666Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. LTD4 hydrolysis

  Catalysed by GLYATL2cytosol

• Cu(2+)Reach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

  Catalysed by PAM, CYBRD1inner side of the membrane, outer side of the membrane

• L-ascorbic acidReach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by PAMOne of 10 routes

• Gly-tRNA(Gly)Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by GLYATL2, GARS1cytosol

• chlorine(.)Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by GLYATL2, SLC6A9, SLC6A14extracellular space, cytosolOne of 3 routes

• glycocholateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GLYATL2, BAATperoxisomeOne of 3 routes

• tetradecanoateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. Myristoyl-CoA hydrolase

  Catalysed by GLYATL2, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 2 routes

• 5-aminolevulinateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by GLYATL2, ALAS1, ALAS2

• glycochenodeoxycholateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by GLYATL2, BAAT

• glycochenodeoxycholic acidReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GLYATL2, BAATperoxisomeOne of 3 routes

• glyoxylateReach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate

  Catalysed by PAMOne of 12 routes

• glycolithocholic acidReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by GLYATL2, BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by GLYATL2, GCATmitochondrial matrix

• L-ornithineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. L-Arginine:glycine amidinotransferase

  Catalysed by GLYATL2, GATMcytosolOne of 5 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by GLYATL2, GLDC, GCSHmitochondrial matrix

• 3-oxohexadecanoyl-CoAReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoA

  Catalysed by GLYATL2, ELOVL6, ELOVL3

• dodecanoyl-CoAReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. Fatty Acid Beta Oxidation (C14->C12), Mitochondrial

  Catalysed by GLYATL2, HADHA, ACADVL, HADHBmitochondrial matrixOne of 2 routes

• sarcosineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by GLYATL2, PIPOXOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by GLYATL2, SHMT1, SHMT2

• an N-acylglycineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by GLYATL2, GLYATL3, GLYAT

• guanidinoacetateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. L-Arginine:glycine amidinotransferase

  Catalysed by GLYATL2, GATMcytosolOne of 2 routes

• L-methionineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glycine and methionine (cytosol to extracellular)

  Catalysed by GLYATL2, SLC7A5extracellular space, cytosolOne of 5 routes

• L-tryptophanReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by GLYATL2, SLC7A5extracellular space, cytosolOne of 5 routes

• glutathioneReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by GLYATL2, GSS

• L-alanineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of alanine and glycine (cytosol to extracellular)

  Catalysed by GLYATL2, SLC3A2, SLC7A5, SLC7A10extracellular space, cytosolOne of 6 routes

• leukotriene C4Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. leukotriene C4 hydrolysis

  Catalysed by GLYATL2cytosol

• L-asparagineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of asparagine and glycine (cytosol to extracellular)

  Catalysed by GLYATL2extracellular space, cytosolOne of 4 routes

• L-phenylalanineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by GLYATL2, SLC7A5extracellular space, cytosolOne of 7 routes

• L-tyrosineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by GLYATL2, AADAT

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by GLYATL2, AGXT2

• an acyl-CoAReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown

  Catalysed by GLYATL2cytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by GLYATL2One of 2 routes

• N-benzoylglycineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. Hippurate (Benzoylglycinate) Formation

  Catalysed by GLYATL2mitochondrial matrixOne of 2 routes

• (2E)-tetradecenoyl-CoAReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. trans-tetradec-2-enoyl-CoA reductase

  Catalysed by GLYATL2, MECRmitochondrial matrixOne of 5 routes

• N-(tetradecanoyl)-sphinganineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. sphinganine + tetradecanoyl-CoA = N-(tetradecanoyl)-sphinganine + CoA + H(+)

  Catalysed by GLYATL2, CERS6, CERS5

• 3-oxohexadecasphinganineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. tetradecanoyl-CoA + L-serine + H(+) = 3-oxohexadecasphinganine + CO2 + CoA

  Catalysed by GLYATL2, SPTLC1, SPTLC3

• 1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. glycerol-3-phosphate 1-O-acyltransferase (myristoyl-CoA)

  Catalysed by GLYATL2, GPAT3, GPAT2, GPAT4 and 1 morecytosol

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GLYATL2, AGPAT2

• (2S)-2-aminobutanoateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by GLYATL2, AGXT2

• 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GLYATL2, AGPAT2, GPAT3, LPCAT2 and 2 more

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. tetradecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by GLYATL2, LPCAT1

• 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by GLYATL2, MOGAT2, MOGAT1